| Sep 24, 1927 | Alabama 46, Millsaps 0 | Box score |
| Sep 24, 1927 | Army 13, Boston University 0 | Box score |
| Sep 24, 1927 | Brown 27, Rhode Island 0 | Box score |
| Sep 24, 1927 | California 14, Santa Clara 6 | Box score |
| Sep 24, 1927 | Carnegie Mellon 25, Westminster (Pennsylvania) 0 | Box score |
| Sep 24, 1927 | Washington State 6, Carroll (Montana) 6 | Box score |
| Sep 24, 1927 | Colgate 21, Hamilton 0 | Box score |
| Sep 24, 1927 | Columbia 32, Vermont 0 | Box score |
| Sep 24, 1927 | Dartmouth 47, Norwich 0 | Box score |
| Sep 24, 1927 | Detroit Mercy 44, Adrian 0 | Box score |
| Sep 24, 1927 | Florida 26, Florida Southern 7 | Box score |
| Sep 24, 1927 | Georgetown 80, Lenoir Rhyne 0 | Box score |
| Sep 24, 1927 | Kansas State 30, Fort Hays 6 | Box score |
| Sep 24, 1927 | Lafayette 39, Schuylkill 13 | Box score |
| Sep 24, 1927 | LSU 45, Louisiana Tech 0 | Box score |
| Sep 24, 1927 | Loyola (LA) 13, Rice 0upset | Box score |
| Sep 24, 1927 | Marquette 29, St. Viator 0 | Box score |
| Sep 24, 1927 | Maryland 80, Washington (Maryland) 0 | Box score |
| Sep 24, 1927 | Kentucky 6, Maryville (TN) 6 | Box score |
| Sep 24, 1927 | Michigan State 12, Kalamazoo 6 | Box score |
| Sep 24, 1927 | Ole Miss 58, Ozarks 0 | Box score |
| Sep 24, 1927 | Montana 19, Centerville (Butte) 0 | Box score |
| Sep 24, 1927 | Montana State 22, North Dakota State 0 | Box score |
| Sep 24, 1927 | New York University 27, Niagara 0 | Box score |
| Sep 24, 1927 | NC State 39, Elon 0 | Box score |
| Sep 24, 1927 | Northern Colorado 16, Hastings State 13 | Box score |
| Sep 24, 1927 | Penn State 27, Lebanon Valley 0 | Box score |
| Sep 24, 1927 | Pennsylvania 8, Franklin & Marshall 0 | Box score |
| Sep 24, 1927 | Pittsburgh 42, Thiel 0 | Box score |
| Sep 24, 1927 | Clemson 0, Presbyterian 0 | Box score |
| Sep 24, 1927 | Sewanee 34, Transylvania 6 | Box score |
| Sep 24, 1927 | South Carolina 13, Erskine 6 | Box score |
| Sep 24, 1927 | USC 33, Occidental 0 | Box score |
| Sep 24, 1927 | Southwestern U 19, Baylor 6upset | Box score |
| Sep 24, 1927 | Stanford 7, Olympic Club 6 | Box score |
| Sep 24, 1927 | Stetson 6, Auburn 0upset | Box score |
| Sep 24, 1927 | Tennessee 33, Carson Newman 0 | Box score |
| Sep 24, 1927 | Texas 43, Southwestern Oklahoma State 0 | Box score |
| Sep 24, 1927 | Texas A&M 45, Trinity (Texas) 0 | Box score |
| Sep 24, 1927 | TCU 27, Daniel Baker 0 | Box score |
| Sep 24, 1927 | Virginia 38, Hampden Sydney 6 | Box score |
| Sep 24, 1927 | Virginia Tech 21, Roanoke 2 | Box score |
| Sep 24, 1927 | Washington 27, USS Idaho 0 | Box score |
| Sep 24, 1927 | Washington & Jefferson 14, Waynesburg 0 | Box score |
| Sep 24, 1927 | Washington and Lee 27, Lynchburg 2 | Box score |
| Sep 24, 1927 | Washington St. Louis 6, Lombard 0 | Box score |
| Sep 24, 1927 | West Virginia 27, West Virginia Wesleyan 7 | Box score |
| Sep 24, 1927 | William Penn 6, Grinnell 6 | Box score |
| Sep 24, 1927 | Wyoming 31, Black Hills State 6 | Box score |
| Sep 25, 1927 | Cornell 41, Clarkson 0 | Box score |
| Sep 25, 1927 | Oregon 7, Linfield 0 | Box score |
| Sep 26, 1927 | Syracuse 13, Hobart 0 | Box score |