| Oct 2, 1925 | Alabama 50, Birmingham-Southern 7 | Box score |
| Oct 2, 1925 | West Virginia Wesleyan 18, Broaddus College 0 | Box score |
| Oct 3, 1925 | Army 31, Detroit Mercy 6 | Box score |
| Oct 3, 1925 | Brown 33, Colby 0 | Box score |
| Oct 3, 1925 | California 54, Nevada 0 | Box score |
| Oct 3, 1925 | Carnegie Mellon 27, Thiel 7 | Box score |
| Oct 3, 1925 | Centre 10, Kentucky Wesleyan 7 | Box score |
| Oct 3, 1925 | The Citadel 27, Rollins 0 | Box score |
| Oct 3, 1925 | Colgate 60, Clarkson 0 | Box score |
| Oct 3, 1925 | Colorado State 34, Regis (CO) 0 | Box score |
| Oct 3, 1925 | Columbia 47, Johns Hopkins 0 | Box score |
| Oct 3, 1925 | Cornell 26, Niagara 0 | Box score |
| Oct 3, 1925 | Cornell (IA) 3, Grinnell 3 | Box score |
| Oct 3, 1925 | Dartmouth 34, Hobart 0 | Box score |
| Oct 3, 1925 | Denver 13, Northern Colorado 0 | Box score |
| Oct 3, 1925 | Gonzaga 45, Carroll (Montana) 0 | Box score |
| Oct 3, 1925 | Harvard 18, Rensselaer 6 | Box score |
| Oct 3, 1925 | Idaho 16, Albertson 14 | Box score |
| Oct 3, 1925 | Indiana 31, Indiana State 0 | Box score |
| Oct 3, 1925 | LSU 38, Louisiana 0 | Box score |
| Oct 3, 1925 | Minnesota 25, North Dakota 0 | Box score |
| Oct 3, 1925 | Mississippi State 34, Millsaps 0 | Box score |
| Oct 3, 1925 | Oregon 0, Multnomah A.C. 0 | Box score |
| Oct 3, 1925 | Northwestern 14, South Dakota 7 | Box score |
| Oct 3, 1925 | Notre Dame 69, Lombard 0 | Box score |
| Oct 3, 1925 | Oglethorpe 7, Samford 6 | Box score |
| Oct 3, 1925 | Ohio State 10, Ohio Wesleyan 3 | Box score |
| Oct 3, 1925 | Oregon State 51, Willamette 0 | Box score |
| Oct 3, 1925 | Parris Island Marines 14, Newberry 0upset | Box score |
| Oct 3, 1925 | Penn State 13, Franklin & Marshall 0 | Box score |
| Oct 3, 1925 | Pennsylvania 26, Swarthmore 13 | Box score |
| Oct 3, 1925 | Presbyterian 35, Erskine 0 | Box score |
| Oct 3, 1925 | Princeton 20, Amherst 0 | Box score |
| Oct 3, 1925 | Richmond 7, Lynchburg 5 | Box score |
| Oct 3, 1925 | Sewanee 53, Middle Tennessee 0 | Box score |
| Oct 3, 1925 | USC 80, Pomona Pitzer 0 | Box score |
| Oct 3, 1925 | SMU 52, Abilene Christian 7 | Box score |
| Oct 3, 1925 | Stanford 20, Santa Clara 3 | Box score |
| Oct 3, 1925 | Syracuse 26, Vermont 0 | Box score |
| Oct 3, 1925 | Tennessee 51, Emory & Henry 0 | Box score |
| Oct 3, 1925 | Texas A&M 23, Southwestern U 6 | Box score |
| Oct 3, 1925 | TCU 12, Daniel Baker 0 | Box score |
| Oct 3, 1925 | Vanderbilt 41, Henderson State 0 | Box score |
| Oct 3, 1925 | Wabash 13, Purdue 7upset | Box score |
| Oct 3, 1925 | Washington 56, West Seattle A.C. 0 | Box score |
| Oct 3, 1925 | Washington & Jefferson 72, Marietta 0 | Box score |
| Oct 3, 1925 | West Virginia 6, Davis & Elkins 0 | Box score |
| Oct 3, 1925 | Wofford 81, Piedmont 0 | Box score |
| Oct 3, 1925 | Wyoming 34, Kearney 0 | Box score |
| Oct 3, 1925 | Yale 53, Middlebury 0 | Box score |