| Sep 25, 1925 | USC 74, Whittier 0 | Box score |
| Sep 26, 1925 | Alabama 53, Union (Tennessee) 0 | Box score |
| Sep 26, 1925 | Auburn 25, Birmingham-Southern 6 | Box score |
| Sep 26, 1925 | Brown 33, Rhode Island 0 | Box score |
| Sep 26, 1925 | California 28, Santa Clara 0 | Box score |
| Sep 26, 1925 | Chadron State 3, Colorado 0upset | Box score |
| Sep 26, 1925 | The Citadel 7, Parris Island Marines 0 | Box score |
| Sep 26, 1925 | Colgate 28, Canisius 0 | Box score |
| Sep 26, 1925 | Columbia 59, Haverford 0 | Box score |
| Sep 26, 1925 | Cornell 80, Susquehanna 0 | Box score |
| Sep 26, 1925 | Dartmouth 59, Norwich 0 | Box score |
| Sep 26, 1925 | Davidson 7, Wofford 0 | Box score |
| Sep 26, 1925 | Duke 33, Guilford 0 | Box score |
| Sep 26, 1925 | Gonzaga 37, Eastern Washington 0 | Box score |
| Sep 26, 1925 | Grinnell 27, William Penn 13 | Box score |
| Sep 26, 1925 | Iowa State 28, Simpson (IA) 0 | Box score |
| Sep 26, 1925 | Kansas State 26, Emporia State 7 | Box score |
| Sep 26, 1925 | Kentucky 13, Maryville (TN) 6 | Box score |
| Sep 26, 1925 | LSU 27, Northwestern State 0 | Box score |
| Sep 26, 1925 | Maryland 13, Washington (Maryland) 0 | Box score |
| Sep 26, 1925 | Michigan State 16, Adrian 0 | Box score |
| Sep 26, 1925 | Ole Miss 53, Arkansas State 0 | Box score |
| Sep 26, 1925 | Montana State 86, Englewood 0 | Box score |
| Sep 26, 1925 | Olympic Club 9, Stanford 0upset | Box score |
| Sep 26, 1925 | Penn State 14, Lebanon Valley 0 | Box score |
| Sep 26, 1925 | Pennsylvania 32, Ursinus 0 | Box score |
| Sep 26, 1925 | Presbyterian 14, Clemson 0upset | Box score |
| Sep 26, 1925 | Rice 33, Stephen F. Austin 0 | Box score |
| Sep 26, 1925 | Virginia Tech 0, Roanoke 0 | Box score |
| Sep 26, 1925 | Sewanee 14, Bryson 0 | Box score |
| Sep 26, 1925 | South Carolina 33, Erskine 0 | Box score |
| Sep 26, 1925 | USC 32, California Tech 0 | Box score |
| Sep 26, 1925 | Syracuse 32, Hobart 0 | Box score |
| Sep 26, 1925 | Texas 33, Southwestern U 0 | Box score |
| Sep 26, 1925 | Texas A&M 20, Trinity (Texas) 10 | Box score |
| Sep 26, 1925 | TCU 31, East Texas A&M 0 | Box score |
| Sep 26, 1925 | Tulane 77, Louisiana Christian 0 | Box score |
| Sep 26, 1925 | Vanderbilt 27, Middle Tennessee 0 | Box score |
| Sep 26, 1925 | VMI 46, Emory & Henry 0 | Box score |
| Sep 26, 1925 | Washington 59, USS Oklahoma 0 | Box score |
| Sep 26, 1925 | Washington & Jefferson 19, Geneva 13 | Box score |
| Sep 26, 1925 | West Virginia 18, Allegheny 0 | Box score |
| Sep 26, 1925 | William & Mary 44, Lenoir Rhyne 0 | Box score |
| Sep 26, 1925 | West Virginia Wesleyan 7, Waynesburg 0 | Box score |