| Sep 29, 1922 | Army 35, Springfield 0 | Box score |
| Sep 29, 1922 | Chattanooga 40, Bryson 0 | Box score |
| Sep 29, 1922 | USC 20, USS Mississippi 0 | Box score |
| Sep 29, 1922 | Texas 19, Austin 0 | Box score |
| Sep 30, 1922 | Alabama 110, Marion 0 | Box score |
| Sep 30, 1922 | Arkansas 39, Hendrix 0 | Box score |
| Sep 30, 1922 | Army 12, Lebanon Valley 0 | Box score |
| Sep 30, 1922 | Auburn 72, Samford 0 | Box score |
| Sep 30, 1922 | Birmingham-Southern 31, Jacksonville State 0 | Box score |
| Sep 30, 1922 | Brown 27, Rhode Island 0 | Box score |
| Sep 30, 1922 | California 45, Santa Clara 14 | Box score |
| Sep 30, 1922 | Colgate 50, Clarkson 6 | Box score |
| Sep 30, 1922 | Columbia 48, Ursinus 7 | Box score |
| Sep 30, 1922 | Cornell 55, St. Bonaventure 6 | Box score |
| Sep 30, 1922 | Dartmouth 20, Norwich 0 | Box score |
| Sep 30, 1922 | Duke 43, Guilford 0 | Box score |
| Sep 30, 1922 | Grinnell 14, Parsons (Iowa) 0 | Box score |
| Sep 30, 1922 | Harvard 20, Middlebury 0 | Box score |
| Sep 30, 1922 | Howard Payne 13, Texas A&M 7upset | Box score |
| Sep 30, 1922 | Kentucky 16, Marshall 0 | Box score |
| Sep 30, 1922 | Lehigh 0, Gettysburg 0 | Box score |
| Sep 30, 1922 | LSU 13, Northwestern State 0 | Box score |
| Sep 30, 1922 | Maryland 7, 3rd Army Corps 0 | Box score |
| Sep 30, 1922 | Mississippi College 22, Louisiana Christian 0 | Box score |
| Sep 30, 1922 | NC State 20, Randolph Macon 2 | Box score |
| Sep 30, 1922 | Notre Dame 46, Kalamazoo 0 | Box score |
| Sep 30, 1922 | Oklahoma State 49, Northwestern (OK) 0 | Box score |
| Sep 30, 1922 | Pennsylvania 14, Franklin & Marshall 0 | Box score |
| Sep 30, 1922 | Pittsburgh 38, Cincinnati 0 | Box score |
| Sep 30, 1922 | Presbyterian 8, Davidson 7upset | Box score |
| Sep 30, 1922 | Princeton 30, Johns Hopkins 0 | Box score |
| Sep 30, 1922 | Rutgers 13, Pennsylvania Military 0 | Box score |
| Sep 30, 1922 | USC 20, Southern California Alumni 0 | Box score |
| Sep 30, 1922 | SMU 16, Southern Methodist Freshmen 0 | Box score |
| Sep 30, 1922 | Syracuse 47, Muhlenberg 0 | Box score |
| Sep 30, 1922 | Talladega 27, Fort Benning 13 | Box score |
| Sep 30, 1922 | Tennessee 32, Carson Newman 7 | Box score |
| Sep 30, 1922 | Ole Miss 0, Union (Tennessee) 0 | Box score |
| Sep 30, 1922 | Utah State 6, Montana Wesleyan 0 | Box score |
| Sep 30, 1922 | Vanderbilt 38, Middle Tennessee 0 | Box score |
| Sep 30, 1922 | Virginia 34, George Washington 0 | Box score |
| Sep 30, 1922 | VMI 34, Lynchburg 7 | Box score |
| Sep 30, 1922 | Virginia Tech 25, King 0 | Box score |
| Sep 30, 1922 | Washington 49, USS Idaho 0 | Box score |
| Sep 30, 1922 | Washington & Jefferson 14, Geneva 0 | Box score |
| Sep 30, 1922 | Washington and Lee 85, Emory & Henry 0 | Box score |
| Sep 30, 1922 | West Virginia 20, West Virginia Wesleyan 3 | Box score |
| Sep 30, 1922 | Wofford 20, North Georgia 0upset | Box score |