1921: Week 2
34 games. Winners are listed first; numbers before names are AP ranks going in.
Everyone else
| Sep 23, 1921 | Chattanooga 20, Athens 0 | Box score |
| Sep 23, 1921 | Colorado College 27, Grand Island 7 | Box score |
| Sep 24, 1921 | Alabama 34, Samford 14 | Box score |
| Sep 24, 1921 | Baylor 35, Tarleton State 0 | Box score |
| Sep 24, 1921 | Beloit 7, Northwestern 0upset | Box score |
| Sep 24, 1921 | Birmingham-Southern 38, Rhodes 6 | Box score |
| Sep 24, 1921 | Brown 6, Rhode Island 0 | Box score |
| Sep 24, 1921 | California 21, Saint Mary’s (CA) 0 | Box score |
| Sep 24, 1921 | Dartmouth 34, Norwich 3 | Box score |
| Sep 24, 1921 | Harvard 16, Middlebury 0 | Box score |
| Sep 24, 1921 | Howard Payne 35, Southwestern U 7upset | Box score |
| Sep 24, 1921 | Indiana 47, Franklin 0 | Box score |
| Sep 24, 1921 | Lafayette 48, Muhlenberg 0 | Box score |
| Sep 24, 1921 | NC State 21, Randolph Macon 0 | Box score |
| Sep 24, 1921 | Notre Dame 56, Kalamazoo 0 | Box score |
| Sep 24, 1921 | Oglethorpe 29, North Georgia 0 | Box score |
| Sep 24, 1921 | Oklahoma State 53, Southwestern Oklahoma State 0 | Box score |
| Sep 24, 1921 | Oregon State 68, Rooks 7 | Box score |
| Sep 24, 1921 | Penn State 53, Lebanon Valley 0 | Box score |
| Sep 24, 1921 | Pennsylvania 89, Delaware 0 | Box score |
| Sep 24, 1921 | Pittsburgh 28, Geneva 0 | Box score |
| Sep 24, 1921 | Rutgers 33, Ursinus 0 | Box score |
| Sep 24, 1921 | Colgate 7, St. Bonaventure 7 | Box score |
| Sep 24, 1921 | Syracuse 35, Hobart 0 | Box score |
| Sep 24, 1921 | Tennessee 27, Emory & Henry 0 | Box score |
| Sep 24, 1921 | TCU 30, West Texas 0 | Box score |
| Sep 24, 1921 | VMI 13, Roanoke 0 | Box score |
| Sep 24, 1921 | Virginia Tech 14, Hampden Sydney 6 | Box score |
| Sep 24, 1921 | Washington & Jefferson 14, Bethany (WV) 0 | Box score |
| Sep 24, 1921 | West Virginia 34, West Virginia Wesleyan 3 | Box score |
| Sep 24, 1921 | Yale 28, Bates 0 | Box score |