| Oct 11, 1916 | Michigan 54, Carroll (WI) 0 | Box score |
| Oct 13, 1916 | Rice 40, Austin 0 | Box score |
| Oct 14, 1916 | Arkansas 82, Oklahoma Mines 0 | Box score |
| Oct 14, 1916 | Baylor 37, Trinity (Texas) 0 | Box score |
| Oct 14, 1916 | Brown 69, Amherst 0 | Box score |
| Oct 14, 1916 | California 21, Whittier 17 | Box score |
| Oct 14, 1916 | The Citadel 34, Presbyterian 7 | Box score |
| Oct 14, 1916 | Colorado College 56, Colorado College Alumni 0 | Box score |
| Oct 14, 1916 | Cornell 42, Williams 0 | Box score |
| Oct 14, 1916 | Dartmouth 62, Massachusetts 0 | Box score |
| Oct 14, 1916 | Furman 60, Erskine 3 | Box score |
| Oct 14, 1916 | Georgetown 60, Eastern (Virginia) 7 | Box score |
| Oct 14, 1916 | Iowa 17, Grinnell 7 | Box score |
| Oct 14, 1916 | Michigan 26, Mount Union 0 | Box score |
| Oct 14, 1916 | Minnesota 47, North Dakota 7 | Box score |
| Oct 14, 1916 | Ole Miss 61, Hendrix 0 | Box score |
| Oct 14, 1916 | Newberry 13, Chick Springs Military 7 | Box score |
| Oct 14, 1916 | Ohio State 128, Oberlin 0 | Box score |
| Oct 14, 1916 | Oregon 28, Multnomah A.C. 0 | Box score |
| Oct 14, 1916 | Princeton 3, Tufts 0 | Box score |
| Oct 14, 1916 | Purdue 28, Wabash 7 | Box score |
| Oct 14, 1916 | Sewanee 68, Maryville (TN) 7 | Box score |
| Oct 14, 1916 | South Carolina 23, Wofford 3 | Box score |
| Oct 14, 1916 | Susquehanna 10, Bucknell 9upset | Box score |
| Oct 14, 1916 | Swarthmore 6, Pennsylvania 0upset | Box score |
| Oct 14, 1916 | Syracuse 60, Franklin & Marshall 0 | Box score |
| Oct 14, 1916 | Tulane 14, Spring Hill 0 | Box score |
| Oct 14, 1916 | Tulsa 16, Oklahoma 0upset | Box score |
| Oct 14, 1916 | Ursinus 6, Lafayette 0upset | Box score |
| Oct 14, 1916 | VMI 54, Gallaudet 0 | Box score |
| Oct 14, 1916 | Washington 28, Ballard Meteors 0 | Box score |
| Oct 14, 1916 | Washington & Jefferson 47, Marietta 6 | Box score |
| Oct 14, 1916 | Wisconsin 28, South Dakota State 3 | Box score |
| Oct 14, 1916 | Yale 12, Lehigh 0 | Box score |