| Sep 28, 1910 | Carlisle 39, Muhlenberg 0 | Box score |
| Sep 28, 1910 | Yale 22, Wesleyan (CT) 0 | Box score |
| Sep 30, 1910 | Missouri 9, Monmouth 0 | Box score |
| Oct 1, 1910 | Alabama 25, Birmingham 0 | Box score |
| Oct 1, 1910 | Arkansas 33, Drury 0 | Box score |
| Oct 1, 1910 | Bethany (WV) 3, Washington & Jefferson 0upset | Box score |
| Oct 1, 1910 | Brown 5, Rhode Island 0 | Box score |
| Oct 1, 1910 | Bucknell 6, Lock Haven 0 | Box score |
| Oct 1, 1910 | Centre 17, Tennessee 2upset | Box score |
| Oct 1, 1910 | Colgate 78, Clarkson 0 | Box score |
| Oct 1, 1910 | Colorado 20, Boulder High 0 | Box score |
| Oct 1, 1910 | Cornell 50, Hobart 0 | Box score |
| Oct 1, 1910 | Denver 11, Denver Alumni 3 | Box score |
| Oct 1, 1910 | Des Moines Baptist 6, Drake 5upset | Box score |
| Oct 1, 1910 | TCU 6, Fort Worth 6 | Box score |
| Oct 1, 1910 | Georgetown 55, Seamen Gunners 0 | Box score |
| Oct 1, 1910 | Georgia 101, Locust Grove 0 | Box score |
| Oct 1, 1910 | Georgia Tech 57, Gordon 0 | Box score |
| Oct 1, 1910 | Harvard 32, Bowdoin 0 | Box score |
| Oct 1, 1910 | Illinois 13, James Millikin 0 | Box score |
| Oct 1, 1910 | Illinois Wesleyan 3, Northwestern 0upset | Box score |
| Oct 1, 1910 | Indiana 12, DePauw 0 | Box score |
| Oct 1, 1910 | Iowa State 12, Coe 0 | Box score |
| Oct 1, 1910 | Kansas 11, Ottawa 0 | Box score |
| Oct 1, 1910 | Kansas State 39, Haskell 0upset | Box score |
| Oct 1, 1910 | Lafayette 10, Ursinus 0 | Box score |
| Oct 1, 1910 | Lehigh 10, McDaniel 0 | Box score |
| Oct 1, 1910 | Minnesota 17, South Dakota 0 | Box score |
| Oct 1, 1910 | Ole Miss 10, Memphis High 0 | Box score |
| Oct 1, 1910 | Mississippi State 24, Mississippi College 0 | Box score |
| Oct 1, 1910 | Navy 16, St. John’s (Maryland) 0 | Box score |
| Oct 1, 1910 | Nebraska 66, Peru State 0 | Box score |
| Oct 1, 1910 | Penn State 58, Harrisburg A.C. 0 | Box score |
| Oct 1, 1910 | Pennsylvania 29, Gettysburg 0 | Box score |
| Oct 1, 1910 | Pittsburgh 36, Ohio Northern 0 | Box score |
| Oct 1, 1910 | Samford 10, Blountsville Agricultural 0 | Box score |
| Oct 1, 1910 | Sewanee 27, Anderson 0 | Box score |
| Oct 1, 1910 | Texas A&M 27, Austin 5 | Box score |
| Oct 1, 1910 | Vanderbilt 23, Rose Hulman 0 | Box score |
| Oct 1, 1910 | Virginia Tech 18, Hampden Sydney 0 | Box score |
| Oct 1, 1910 | Washington and Lee 13, Roanoke 0 | Box score |
| Oct 1, 1910 | Waynesburg 0, Carnegie Mellon 0 | Box score |
| Oct 1, 1910 | Wyoming 61, Cheyenne High 12 | Box score |
| Oct 2, 1910 | Iowa 12, Morningside 0 | Box score |