| Sep 30, 1908 | Pennsylvania 30, Ursinus 0 | Box score |
| Sep 30, 1908 | Yale 16, Wesleyan (CT) 0 | Box score |
| Oct 3, 1908 | Alabama 27, Wetumpka 0 | Box score |
| Oct 3, 1908 | Army 5, Tufts 0 | Box score |
| Oct 3, 1908 | Auburn 18, Samford 0 | Box score |
| Oct 3, 1908 | Colorado College 29, Colorado Springs High 0 | Box score |
| Oct 3, 1908 | Cornell 11, Hamilton 0 | Box score |
| Oct 3, 1908 | Denver 47, Denver Manual High 0 | Box score |
| Oct 3, 1908 | Dickinson 16, Franklin & Marshall 0 | Box score |
| Oct 3, 1908 | Drake 4, Drake Alumni 0 | Box score |
| Oct 3, 1908 | George Washington 18, McDaniel 0 | Box score |
| Oct 3, 1908 | Georgetown 15, Gallaudet 0 | Box score |
| Oct 3, 1908 | Georgia 16, North Georgia 0 | Box score |
| Oct 3, 1908 | Georgia Tech 32, Gordon 0 | Box score |
| Oct 3, 1908 | Harvard 18, Bates 0 | Box score |
| Oct 3, 1908 | Illinois 17, Monmouth 6 | Box score |
| Oct 3, 1908 | Indiana 16, DePauw 0 | Box score |
| Oct 3, 1908 | Iowa State 34, Coe 0 | Box score |
| Oct 3, 1908 | Kansas 24, St. Mary’s (Kansas) 0 | Box score |
| Oct 3, 1908 | Lafayette 22, Stroudsburg 0 | Box score |
| Oct 3, 1908 | LSU 41, New Orleans Gym Club 0 | Box score |
| Oct 3, 1908 | Michigan 16, Case 6 | Box score |
| Oct 3, 1908 | Minnesota 6, Lawrence 0 | Box score |
| Oct 3, 1908 | Ole Miss 30, Tennessee–Memphis 0 | Box score |
| Oct 3, 1908 | Missouri 57, Central Missouri 6 | Box score |
| Oct 3, 1908 | Nebraska 43, Doane 0 | Box score |
| Oct 3, 1908 | Pittsburgh 27, Bethany (WV) 0 | Box score |
| Oct 3, 1908 | Princeton 21, Stevens 0 | Box score |
| Oct 3, 1908 | Saint Louis 17, Missouri–Rolla 0 | Box score |
| Oct 3, 1908 | Sewanee 29, Mooney 0 | Box score |
| Oct 3, 1908 | Texas A&M 6, Trinity (Texas) 0 | Box score |
| Oct 3, 1908 | Vanderbilt 32, Maryville (TN) 0 | Box score |
| Oct 3, 1908 | Virginia Tech 50, Hampden Sydney 0 | Box score |
| Oct 3, 1908 | Wake Forest 21, Warrenton Preparatory 0 | Box score |
| Oct 3, 1908 | Washington & Jefferson 29, Geneva 0 | Box score |
| Oct 3, 1908 | Washington and Lee 27, Roanoke 0 | Box score |
| Oct 3, 1908 | Washington St. Louis 0, Carleton 0 | Box score |
| Oct 4, 1908 | Colorado 6, Longmont High 0 | Box score |
| Oct 4, 1908 | Navy 22, St. John’s (Maryland) 0 | Box score |