| Sep 24, 1998 | 16Arizona 35, San Diego State 16 | Box score |
| Sep 26, 1998 | Akron 52, Ball State 14 | Box score |
| Sep 26, 1998 | Arizona State 24, Oregon State 3 | Box score |
| Sep 26, 1998 | Arkansas 42, 22Alabama 6upset | Box score |
| Sep 26, 1998 | Arkansas State 20, Hawai’i 0 | Box score |
| Sep 26, 1998 | Boise State 31, Utah 28upset | Box score |
| Sep 26, 1998 | California 24, Washington State 14 | Box score |
| Sep 26, 1998 | UCF 38, Bowling Green 31 | Box score |
| Sep 26, 1998 | Central Michigan 46, Kent State 7 | Box score |
| Sep 26, 1998 | 15Colorado 18, Baylor 16 | Box score |
| Sep 26, 1998 | Colorado State 38, UNLV 16 | Box score |
| Sep 26, 1998 | 8Florida 51, Kentucky 35 | Box score |
| Sep 26, 1998 | 10Florida State 30, 18USC 10 | Box score |
| Sep 26, 1998 | Georgia Tech 43, North Carolina 21upset | Box score |
| Sep 26, 1998 | Indiana 48, Cincinnati 14 | Box score |
| Sep 26, 1998 | Iowa 37, Illinois 14 | Box score |
| Sep 26, 1998 | Kansas 39, UAB 37 | Box score |
| Sep 26, 1998 | 5Kansas State 62, UL Monroe 7 | Box score |
| Sep 26, 1998 | 6LSU 53, Idaho 20 | Box score |
| Sep 26, 1998 | Louisville 52, Boston College 28 | Box score |
| Sep 26, 1998 | Marshall 26, Eastern Michigan 23 | Box score |
| Sep 26, 1998 | Maryland 30, Temple 20 | Box score |
| Sep 26, 1998 | Miami (OH) 28, Toledo 14 | Box score |
| Sep 26, 1998 | Michigan 29, Michigan State 17 | Box score |
| Sep 26, 1998 | Ole Miss 48, SMU 41 | Box score |
| Sep 26, 1998 | Mississippi State 38, South Carolina 0 | Box score |
| Sep 26, 1998 | 2Nebraska 55, 9Washington 7 | Box score |
| Sep 26, 1998 | Nevada 27, Fresno State 24 | Box score |
| Sep 26, 1998 | New Mexico State 33, UTEP 24 | Box score |
| Sep 26, 1998 | 23Notre Dame 31, Purdue 30 | Box score |
| Sep 26, 1998 | Ohio 37, Western Michigan 35 | Box score |
| Sep 26, 1998 | 20Oregon 63, Stanford 28 | Box score |
| Sep 26, 1998 | Rutgers 27, Army 15 | Box score |
| Sep 26, 1998 | San José State 37, New Mexico 20 | Box score |
| Sep 26, 1998 | Southern Miss 55, Louisiana 0 | Box score |
| Sep 26, 1998 | 4Tennessee 42, Houston 7 | Box score |
| Sep 26, 1998 | Texas 59, Rice 21 | Box score |
| Sep 26, 1998 | 17Texas A&M 28, North Texas 9 | Box score |
| Sep 26, 1998 | TCU 35, 23Air Force 34upset | Box score |
| Sep 26, 1998 | Texas Tech 31, Iowa State 24 | Box score |
| Sep 26, 1998 | Tulane 42, Navy 24 | Box score |
| Sep 26, 1998 | 11Virginia 24, Duke 0 | Box score |
| Sep 26, 1998 | 21Virginia Tech 27, Pittsburgh 7 | Box score |
| Sep 26, 1998 | Wake Forest 29, Clemson 19upset | Box score |
| Sep 26, 1998 | 19West Virginia 44, Tulsa 21 | Box score |
| Sep 26, 1998 | 14Wisconsin 38, Northwestern 7 | Box score |
| Sep 26, 1998 | Wyoming 31, Louisiana Tech 19 | Box score |