| Sep 10, 1992 | San Diego State 45, 25BYU 38upset | Box score |
| Sep 12, 1992 | Akron 23, Toledo 20 | Box score |
| Sep 12, 1992 | 8Alabama 17, Southern Miss 10 | Box score |
| Sep 12, 1992 | Arkansas 45, South Carolina 7 | Box score |
| Sep 12, 1992 | Boston College 49, Northwestern 0 | Box score |
| Sep 12, 1992 | Central Michigan 24, Michigan State 20 | Box score |
| Sep 12, 1992 | 12Colorado 57, Baylor 38 | Box score |
| Sep 12, 1992 | East Carolina 30, Virginia Tech 27 | Box score |
| Sep 12, 1992 | 4Florida 35, Kentucky 19 | Box score |
| Sep 12, 1992 | 5Florida State 24, 15Clemson 20 | Box score |
| Sep 12, 1992 | Hawai’i 6, Air Force 3upset | Box score |
| Sep 12, 1992 | Illinois 24, Missouri 17 | Box score |
| Sep 12, 1992 | Indiana 16, Miami (OH) 0 | Box score |
| Sep 12, 1992 | Iowa 21, Iowa State 7 | Box score |
| Sep 12, 1992 | Kansas 62, Ball State 10 | Box score |
| Sep 12, 1992 | LSU 24, 18Mississippi State 3upset | Box score |
| Sep 12, 1992 | Louisiana Tech 31, Eastern Michigan 17 | Box score |
| Sep 12, 1992 | Louisville 16, Memphis 15 | Box score |
| Sep 12, 1992 | 3Notre Dame 17, 6Michigan 17 | Box score |
| Sep 12, 1992 | Ole Miss 35, Tulane 9 | Box score |
| Sep 12, 1992 | Nevada 20, Pacific 14 | Box score |
| Sep 12, 1992 | UNLV 19, UTEP 17 | Box score |
| Sep 12, 1992 | New Mexico State 42, New Mexico 39 | Box score |
| Sep 12, 1992 | 19NC State 14, Maryland 10 | Box score |
| Sep 12, 1992 | Ohio 27, Kent State 14 | Box score |
| Sep 12, 1992 | 22Ohio State 17, Bowling Green 6 | Box score |
| Sep 12, 1992 | 13Oklahoma 61, Arkansas State 0 | Box score |
| Sep 12, 1992 | Oregon State 46, Fresno State 36upset | Box score |
| Sep 12, 1992 | 10Penn State 49, Temple 8 | Box score |
| Sep 12, 1992 | Purdue 41, 17California 14upset | Box score |
| Sep 12, 1992 | San José State 39, Minnesota 30 | Box score |
| Sep 12, 1992 | 21Stanford 21, Oregon 7 | Box score |
| Sep 12, 1992 | 9Syracuse 31, Texas 21 | Box score |
| Sep 12, 1992 | 20Tennessee 34, 14Georgia 31upset | Box score |
| Sep 12, 1992 | 7Texas A&M 19, Tulsa 9 | Box score |
| Sep 12, 1992 | Texas Tech 49, Wyoming 32 | Box score |
| Sep 12, 1992 | 16UCLA 37, Cal State Fullerton 14 | Box score |
| Sep 12, 1992 | Utah 42, Utah State 18 | Box score |
| Sep 12, 1992 | Vanderbilt 42, Duke 37 | Box score |
| Sep 12, 1992 | 23Virginia 53, Navy 0 | Box score |
| Sep 12, 1992 | 2Washington 27, Wisconsin 10 | Box score |
| Sep 12, 1992 | Washington State 23, Arizona 20 | Box score |
| Sep 12, 1992 | West Virginia 44, Pittsburgh 6 | Box score |
| Sep 12, 1992 | TCU 17, Western Michigan 17 | Box score |