| Sep 12, 1987 | Air Force 21, TCU 10 | Box score |
| Sep 12, 1987 | 19Alabama 24, 11Penn State 13upset | Box score |
| Sep 12, 1987 | 15Arizona State 21, Illinois 7 | Box score |
| Sep 12, 1987 | 13Arkansas 31, Ole Miss 10 | Box score |
| Sep 12, 1987 | 4Auburn 49, Kansas 0 | Box score |
| Sep 12, 1987 | Boston College 28, Temple 7 | Box score |
| Sep 12, 1987 | BYU 22, Texas 17 | Box score |
| Sep 12, 1987 | Cincinnati 25, Louisville 0 | Box score |
| Sep 12, 1987 | 10Clemson 22, Virginia Tech 10 | Box score |
| Sep 12, 1987 | Duke 31, Northwestern 16 | Box score |
| Sep 12, 1987 | Eastern Michigan 33, Miami (OH) 17upset | Box score |
| Sep 12, 1987 | Florida 52, Tulsa 0 | Box score |
| Sep 12, 1987 | 8Florida State 44, East Carolina 3 | Box score |
| Sep 12, 1987 | 20Georgia 41, Oregon State 7 | Box score |
| Sep 12, 1987 | Indiana 35, Rice 13 | Box score |
| Sep 12, 1987 | Iowa 15, Arizona 14 | Box score |
| Sep 12, 1987 | Kent State 27, Akron 23 | Box score |
| Sep 12, 1987 | Kentucky 41, Utah State 0 | Box score |
| Sep 12, 1987 | Louisiana 21, UNLV 10 | Box score |
| Sep 12, 1987 | 6LSU 56, Cal State Fullerton 12 | Box score |
| Sep 12, 1987 | Maryland 21, Virginia 19 | Box score |
| Sep 12, 1987 | Missouri 23, Baylor 18upset | Box score |
| Sep 12, 1987 | 2Nebraska 42, 3UCLA 33 | Box score |
| Sep 12, 1987 | New Mexico State 17, New Mexico 14 | Box score |
| Sep 12, 1987 | 16Notre Dame 26, 9Michigan 7upset | Box score |
| Sep 12, 1987 | 5Ohio State 24, West Virginia 3 | Box score |
| Sep 12, 1987 | 1Oklahoma 28, North Carolina 0 | Box score |
| Sep 12, 1987 | Oklahoma State 35, Houston 0 | Box score |
| Sep 12, 1987 | Oregon 10, Colorado 7 | Box score |
| Sep 12, 1987 | 18Pittsburgh 34, NC State 0 | Box score |
| Sep 12, 1987 | San Diego State 52, Utah 34 | Box score |
| Sep 12, 1987 | San José State 27, California 25 | Box score |
| Sep 12, 1987 | Syracuse 20, Rutgers 3 | Box score |
| Sep 12, 1987 | 14Tennessee 38, Mississippi State 10 | Box score |
| Sep 12, 1987 | Texas Tech 33, Colorado State 24 | Box score |
| Sep 12, 1987 | Toledo 21, Ball State 17 | Box score |
| Sep 12, 1987 | Tulane 25, Iowa State 12 | Box score |
| Sep 12, 1987 | Vanderbilt 27, Memphis 17 | Box score |
| Sep 12, 1987 | 12Washington 28, Purdue 10 | Box score |
| Sep 12, 1987 | Washington State 43, Wyoming 28 | Box score |
| Sep 12, 1987 | Wisconsin 28, Hawai’i 7 | Box score |