| Oct 18, 1980 | 1Alabama 27, Tennessee 0 | Box score |
| Oct 18, 1980 | Auburn 17, Georgia Tech 14 | Box score |
| Oct 18, 1980 | Ball State 26, Eastern Michigan 0 | Box score |
| Oct 18, 1980 | 13Baylor 46, Texas A&M 7 | Box score |
| Oct 18, 1980 | Bowling Green 24, Kent State 3 | Box score |
| Oct 18, 1980 | BYU 70, Utah State 46 | Box score |
| Oct 18, 1980 | Brown 32, Cornell 25 | Box score |
| Oct 18, 1980 | California 27, Oregon State 6 | Box score |
| Oct 18, 1980 | Chattanooga 21, Marshall 11 | Box score |
| Oct 18, 1980 | Colorado State 26, San Diego State 7 | Box score |
| Oct 18, 1980 | Dartmouth 30, Harvard 12 | Box score |
| Oct 18, 1980 | Drake 27, West Texas 21 | Box score |
| Oct 18, 1980 | Duke 34, Clemson 17upset | Box score |
| Oct 18, 1980 | East Carolina 24, Western Carolina 14 | Box score |
| Oct 18, 1980 | Florida 15, Ole Miss 3 | Box score |
| Oct 18, 1980 | 7Florida State 41, Boston College 7 | Box score |
| Oct 18, 1980 | Fresno State 27, Pacific 3 | Box score |
| Oct 18, 1980 | 6Georgia 41, Vanderbilt 0 | Box score |
| Oct 18, 1980 | Hawai’i 31, New Mexico 14 | Box score |
| Oct 18, 1980 | Houston 13, SMU 11 | Box score |
| Oct 18, 1980 | Iowa 25, Northwestern 3 | Box score |
| Oct 18, 1980 | Kansas 28, 19Iowa State 17upset | Box score |
| Oct 18, 1980 | Long Beach State 23, San José State 21upset | Box score |
| Oct 18, 1980 | LSU 17, Kentucky 10 | Box score |
| Oct 18, 1980 | UL Monroe 28, Lamar 6 | Box score |
| Oct 18, 1980 | Louisville 27, Indiana State 17 | Box score |
| Oct 18, 1980 | Maryland 11, Wake Forest 10 | Box score |
| Oct 18, 1980 | Michigan 37, Minnesota 14 | Box score |
| Oct 18, 1980 | Mississippi State 34, 18Miami 31upset | Box score |
| Oct 18, 1980 | 16Missouri 45, Colorado 7 | Box score |
| Oct 18, 1980 | Navy 24, Villanova 15 | Box score |
| Oct 18, 1980 | 10Nebraska 48, Oklahoma State 7 | Box score |
| Oct 18, 1980 | UNLV 53, UTEP 14 | Box score |
| Oct 18, 1980 | New Mexico State 30, Texas–Arlington 10upset | Box score |
| Oct 18, 1980 | 8North Carolina 28, NC State 8 | Box score |
| Oct 18, 1980 | North Texas 29, Memphis 10 | Box score |
| Oct 18, 1980 | Northern Illinois 21, Central Michigan 0upset | Box score |
| Oct 18, 1980 | 5Notre Dame 30, Army 3 | Box score |
| Oct 18, 1980 | Ohio 17, Miami (OH) 7 | Box score |
| Oct 18, 1980 | 9Ohio State 27, Indiana 17 | Box score |
| Oct 18, 1980 | 17Oklahoma 35, Kansas State 21 | Box score |
| Oct 18, 1980 | 12Penn State 24, Syracuse 7 | Box score |
| Oct 18, 1980 | 11Pittsburgh 42, West Virginia 14 | Box score |
| Oct 18, 1980 | Princeton 14, Colgate 10 | Box score |
| Oct 18, 1980 | Purdue 45, Illinois 20 | Box score |
| Oct 18, 1980 | 15South Carolina 49, Cincinnati 7 | Box score |
| Oct 18, 1980 | Oregon 7, 2USC 7 | Box score |
| Oct 18, 1980 | Southern Illinois 42, Illinois State 0 | Box score |
| Oct 18, 1980 | Southern Miss 35, Arkansas State 0 | Box score |
| Oct 18, 1980 | Texas Tech 10, Rice 3 | Box score |
| Oct 18, 1980 | Tulane 28, Air Force 7 | Box score |
| Oct 18, 1980 | Tulsa 23, TCU 17 | Box score |
| Oct 18, 1980 | VMI 22, Richmond 17 | Box score |
| Oct 18, 1980 | Virginia Tech 30, Virginia 0 | Box score |
| Oct 18, 1980 | Washington 27, 20Stanford 24upset | Box score |
| Oct 18, 1980 | Washington State 38, Arizona 14upset | Box score |
| Oct 18, 1980 | Western Michigan 17, Toledo 7 | Box score |
| Oct 18, 1980 | William & Mary 21, Rutgers 18upset | Box score |
| Oct 18, 1980 | Wisconsin 17, Michigan State 7 | Box score |
| Oct 18, 1980 | Wyoming 24, Utah 21 | Box score |
| Oct 18, 1980 | Yale 30, Columbia 10 | Box score |