| Oct 11, 1980 | Air Force 21, Navy 20upset | Box score |
| Oct 11, 1980 | 1Alabama 17, Rutgers 13 | Box score |
| Oct 11, 1980 | Arizona State 27, Washington State 21 | Box score |
| Oct 11, 1980 | 15Arkansas 27, Wichita State 7 | Box score |
| Oct 11, 1980 | 18Baylor 32, 20SMU 28 | Box score |
| Oct 11, 1980 | Boston College 27, Yale 9upset | Box score |
| Oct 11, 1980 | Bowling Green 17, Toledo 6upset | Box score |
| Oct 11, 1980 | BYU 52, Wyoming 17 | Box score |
| Oct 11, 1980 | Brown 42, Pennsylvania 22 | Box score |
| Oct 11, 1980 | California 31, Oregon 6 | Box score |
| Oct 11, 1980 | Chattanooga 55, VMI 10 | Box score |
| Oct 11, 1980 | The Citadel 28, Western Carolina 21 | Box score |
| Oct 11, 1980 | Clemson 27, Virginia 24 | Box score |
| Oct 11, 1980 | Colgate 38, Holy Cross 7 | Box score |
| Oct 11, 1980 | Colorado State 31, New Mexico 26upset | Box score |
| Oct 11, 1980 | Drake 41, Colorado 22 | Box score |
| Oct 11, 1980 | East Carolina 24, Richmond 22 | Box score |
| Oct 11, 1980 | 11Florida State 36, 4Pittsburgh 22upset | Box score |
| Oct 11, 1980 | 6Georgia 28, Ole Miss 21 | Box score |
| Oct 11, 1980 | Harvard 20, Cornell 12 | Box score |
| Oct 11, 1980 | Hawai’i 16, West Virginia 13 | Box score |
| Oct 11, 1980 | Houston 17, Texas A&M 7 | Box score |
| Oct 11, 1980 | Illinois 20, Iowa 14upset | Box score |
| Oct 11, 1980 | Illinois State 28, Northern Illinois 18upset | Box score |
| Oct 11, 1980 | Indiana 24, Wisconsin 0 | Box score |
| Oct 11, 1980 | Indiana State 19, Southern Illinois 6 | Box score |
| Oct 11, 1980 | Iowa State 31, Kansas State 7 | Box score |
| Oct 11, 1980 | Long Beach State 17, Pacific 12 | Box score |
| Oct 11, 1980 | Louisiana 3, Arkansas State 0 | Box score |
| Oct 11, 1980 | LSU 21, Auburn 17 | Box score |
| Oct 11, 1980 | Louisiana Tech 16, Lamar 7 | Box score |
| Oct 11, 1980 | Louisville 38, Memphis 14 | Box score |
| Oct 11, 1980 | McNeese 48, UL Monroe 28 | Box score |
| Oct 11, 1980 | Miami (OH) 34, Marshall 6 | Box score |
| Oct 11, 1980 | Michigan 27, Michigan State 23 | Box score |
| Oct 11, 1980 | 19Missouri 30, Oklahoma State 7 | Box score |
| Oct 11, 1980 | 10Nebraska 54, Kansas 0 | Box score |
| Oct 11, 1980 | UNLV 28, San Diego State 17 | Box score |
| Oct 11, 1980 | 8North Carolina 27, Wake Forest 9 | Box score |
| Oct 11, 1980 | NC State 17, App State 14 | Box score |
| Oct 11, 1980 | 7Notre Dame 32, 13Miami 14 | Box score |
| Oct 11, 1980 | Ohio 24, Central Michigan 9upset | Box score |
| Oct 11, 1980 | 9Ohio State 63, Northwestern 0 | Box score |
| Oct 11, 1980 | 14Penn State 24, Maryland 10 | Box score |
| Oct 11, 1980 | Princeton 31, Columbia 19 | Box score |
| Oct 11, 1980 | Purdue 21, Minnesota 7 | Box score |
| Oct 11, 1980 | Rice 28, TCU 24 | Box score |
| Oct 11, 1980 | San José State 26, Fresno State 14 | Box score |
| Oct 11, 1980 | 17South Carolina 20, Duke 7 | Box score |
| Oct 11, 1980 | 2USC 27, Arizona 10 | Box score |
| Oct 11, 1980 | Southern Miss 42, Mississippi State 14 | Box score |
| Oct 11, 1980 | Syracuse 31, Temple 7 | Box score |
| Oct 11, 1980 | Tennessee 23, Georgia Tech 10 | Box score |
| Oct 11, 1980 | 3Texas 20, 12Oklahoma 13 | Box score |
| Oct 11, 1980 | Tulane 43, Vanderbilt 21 | Box score |
| Oct 11, 1980 | Tulsa 28, North Texas 27 | Box score |
| Oct 11, 1980 | 5UCLA 35, 16Stanford 21 | Box score |
| Oct 11, 1980 | Utah 31, UTEP 7 | Box score |
| Oct 11, 1980 | Utah State 28, Cal State Fullerton 17 | Box score |
| Oct 11, 1980 | Washington 41, Oregon State 6 | Box score |
| Oct 11, 1980 | West Texas 38, Texas–Arlington 26 | Box score |
| Oct 11, 1980 | Western Michigan 28, Kent State 21 | Box score |
| Oct 11, 1980 | William & Mary 17, Dartmouth 14 | Box score |