| Oct 22, 1977 | 3Alabama 55, Louisville 6 | Box score |
| Oct 22, 1977 | Alcorn State 23, Southern 0upset | Box score |
| Oct 22, 1977 | Arizona 45, Utah 17 | Box score |
| Oct 22, 1977 | Arizona State 66, UTEP 3 | Box score |
| Oct 22, 1977 | 9Arkansas 34, Houston 0 | Box score |
| Oct 22, 1977 | Baylor 38, Air Force 7 | Box score |
| Oct 22, 1977 | Boston College 17, Villanova 0 | Box score |
| Oct 22, 1977 | 17BYU 10, Wyoming 7 | Box score |
| Oct 22, 1977 | Brown 44, Holy Cross 13 | Box score |
| Oct 22, 1977 | Cincinnati 28, Tulsa 0 | Box score |
| Oct 22, 1977 | 20Clemson 7, NC State 3 | Box score |
| Oct 22, 1977 | Colgate 48, Columbia 36 | Box score |
| Oct 22, 1977 | Colorado State 14, New Mexico 9 | Box score |
| Oct 22, 1977 | Dartmouth 17, Cornell 13 | Box score |
| Oct 22, 1977 | East Carolina 34, The Citadel 16 | Box score |
| Oct 22, 1977 | 19Florida 27, Tennessee 17 | Box score |
| Oct 22, 1977 | Florida State 24, Auburn 3 | Box score |
| Oct 22, 1977 | Fresno State 45, San José State 24 | Box score |
| Oct 22, 1977 | Furman 28, App State 20 | Box score |
| Oct 22, 1977 | Georgia Tech 38, Tulane 14 | Box score |
| Oct 22, 1977 | Grambling 34, Jackson State 7upset | Box score |
| Oct 22, 1977 | Illinois 21, Indiana 7 | Box score |
| Oct 22, 1977 | Indiana State 20, Illinois State 10 | Box score |
| Oct 22, 1977 | Kent State 29, Eastern Michigan 13 | Box score |
| Oct 22, 1977 | 8Kentucky 33, Georgia 0 | Box score |
| Oct 22, 1977 | LSU 56, Oregon 17 | Box score |
| Oct 22, 1977 | Maryland 31, Duke 13 | Box score |
| Oct 22, 1977 | McNeese 17, Arkansas State 14 | Box score |
| Oct 22, 1977 | Miami (OH) 33, Bowling Green 13 | Box score |
| Oct 22, 1977 | Michigan State 9, Wisconsin 7upset | Box score |
| Oct 22, 1977 | Minnesota 16, 1Michigan 0upset | Box score |
| Oct 22, 1977 | Ole Miss 26, Vanderbilt 14 | Box score |
| Oct 22, 1977 | Missouri 28, Kansas State 13 | Box score |
| Oct 22, 1977 | Navy 42, William & Mary 17 | Box score |
| Oct 22, 1977 | 18Nebraska 33, 7Colorado 15upset | Box score |
| Oct 22, 1977 | New Mexico State 7, Texas–Arlington 6upset | Box score |
| Oct 22, 1977 | North Carolina 17, South Carolina 0 | Box score |
| Oct 22, 1977 | North Texas 20, Memphis 19 | Box score |
| Oct 22, 1977 | Northern Illinois 28, Southern Illinois 0upset | Box score |
| Oct 22, 1977 | 11Notre Dame 49, 5USC 19upset | Box score |
| Oct 22, 1977 | 4Ohio State 35, Northwestern 15 | Box score |
| Oct 22, 1977 | 6Oklahoma 35, 16Iowa State 16 | Box score |
| Oct 22, 1977 | Oklahoma State 21, Kansas 0 | Box score |
| Oct 22, 1977 | Pacific 22, Long Beach State 7upset | Box score |
| Oct 22, 1977 | 10Penn State 49, West Virginia 28 | Box score |
| Oct 22, 1977 | 14Pittsburgh 28, Syracuse 21 | Box score |
| Oct 22, 1977 | Princeton 20, Harvard 7upset | Box score |
| Oct 22, 1977 | Purdue 34, Iowa 21 | Box score |
| Oct 22, 1977 | Richmond 17, Virginia Tech 14 | Box score |
| Oct 22, 1977 | Southern Miss 14, Mississippi State 7upset | Box score |
| Oct 22, 1977 | Stanford 31, Washington State 29 | Box score |
| Oct 22, 1977 | Temple 27, Louisiana 20 | Box score |
| Oct 22, 1977 | 2Texas 30, SMU 14 | Box score |
| Oct 22, 1977 | 12Texas A&M 28, Rice 14 | Box score |
| Oct 22, 1977 | TCU 21, Miami 17upset | Box score |
| Oct 22, 1977 | Toledo 31, Ohio 29 | Box score |
| Oct 22, 1977 | UCLA 21, 15California 19upset | Box score |
| Oct 22, 1977 | Virginia 12, Wake Forest 10 | Box score |
| Oct 22, 1977 | Washington 14, Oregon State 6 | Box score |
| Oct 22, 1977 | West Texas 27, Lamar 9 | Box score |
| Oct 22, 1977 | Western Michigan 53, Marshall 29 | Box score |
| Oct 22, 1977 | Wichita State 47, Drake 17 | Box score |
| Oct 22, 1977 | Yale 27, Pennsylvania 21 | Box score |