| Oct 24, 1975 | West Virginia 10, Virginia Tech 7 | Box score |
| Oct 25, 1975 | 6Alabama 45, TCU 0 | Box score |
| Oct 25, 1975 | 11Arizona State 24, UTEP 6 | Box score |
| Oct 25, 1975 | Arkansas 31, Utah State 0 | Box score |
| Oct 25, 1975 | Arkansas State 17, Lamar 0 | Box score |
| Oct 25, 1975 | Auburn 17, Florida State 14 | Box score |
| Oct 25, 1975 | Ball State 3, Northern Illinois 0 | Box score |
| Oct 25, 1975 | BYU 33, Wyoming 20 | Box score |
| Oct 25, 1975 | Central Michigan 17, Kent State 8upset | Box score |
| Oct 25, 1975 | Cincinnati 23, Louisiana 17 | Box score |
| Oct 25, 1975 | The Citadel 6, VMI 3 | Box score |
| Oct 25, 1975 | Colorado State 47, Air Force 10 | Box score |
| Oct 25, 1975 | Dayton 17, McNeese 12 | Box score |
| Oct 25, 1975 | East Carolina 38, North Carolina 17 | Box score |
| Oct 25, 1975 | 12Florida 24, Duke 16 | Box score |
| Oct 25, 1975 | Furman 21, William & Mary 6 | Box score |
| Oct 25, 1975 | Georgia 21, Kentucky 13 | Box score |
| Oct 25, 1975 | Georgia Tech 23, Tulane 0 | Box score |
| Oct 25, 1975 | Harvard 24, Dartmouth 10 | Box score |
| Oct 25, 1975 | Holy Cross 21, Brown 20upset | Box score |
| Oct 25, 1975 | Illinois 21, 16Michigan State 19upset | Box score |
| Oct 25, 1975 | Long Beach State 31, Drake 10 | Box score |
| Oct 25, 1975 | LSU 24, 20South Carolina 6upset | Box score |
| Oct 25, 1975 | Marshall 21, Western Michigan 19 | Box score |
| Oct 25, 1975 | Memphis 16, Tulsa 14upset | Box score |
| Oct 25, 1975 | Miami (OH) 20, Bowling Green 17 | Box score |
| Oct 25, 1975 | 7Michigan 55, Indiana 7 | Box score |
| Oct 25, 1975 | Minnesota 31, Iowa 7 | Box score |
| Oct 25, 1975 | Ole Miss 17, Vanderbilt 7 | Box score |
| Oct 25, 1975 | Mississippi State 28, Louisville 14 | Box score |
| Oct 25, 1975 | 15Missouri 35, Kansas State 3 | Box score |
| Oct 25, 1975 | Navy 17, 17Pittsburgh 0upset | Box score |
| Oct 25, 1975 | 4Nebraska 63, 10Colorado 21 | Box score |
| Oct 25, 1975 | New Mexico 44, 13Arizona 34upset | Box score |
| Oct 25, 1975 | New Mexico State 16, Texas–Arlington 0 | Box score |
| Oct 25, 1975 | NC State 45, Clemson 7 | Box score |
| Oct 25, 1975 | North Texas 21, Tennessee 14upset | Box score |
| Oct 25, 1975 | 1Ohio State 35, Purdue 6 | Box score |
| Oct 25, 1975 | 2Oklahoma 39, Iowa State 7 | Box score |
| Oct 25, 1975 | Oklahoma State 35, Kansas 19 | Box score |
| Oct 25, 1975 | Oregon 18, Utah 7 | Box score |
| Oct 25, 1975 | Pacific 45, Fresno State 28 | Box score |
| Oct 25, 1975 | 9Penn State 31, Army 0 | Box score |
| Oct 25, 1975 | Pennsylvania 24, Princeton 20upset | Box score |
| Oct 25, 1975 | Richmond 24, App State 17 | Box score |
| Oct 25, 1975 | Rutgers 41, Columbia 0 | Box score |
| Oct 25, 1975 | San José State 41, Cal State Fullerton 7 | Box score |
| Oct 25, 1975 | 3USC 24, 14Notre Dame 17 | Box score |
| Oct 25, 1975 | Southern Illinois 33, Wichita State 22 | Box score |
| Oct 25, 1975 | Southern Miss 24, Louisiana Tech 14upset | Box score |
| Oct 25, 1975 | Stanford 54, Washington State 14 | Box score |
| Oct 25, 1975 | Syracuse 22, Boston College 14 | Box score |
| Oct 25, 1975 | 8Texas 41, Rice 9 | Box score |
| Oct 25, 1975 | 5Texas A&M 19, Baylor 10 | Box score |
| Oct 25, 1975 | Texas Tech 37, SMU 20 | Box score |
| Oct 25, 1975 | Toledo 14, Ohio 10 | Box score |
| Oct 25, 1975 | 19UCLA 28, California 14 | Box score |
| Oct 25, 1975 | Wake Forest 66, Virginia 21 | Box score |
| Oct 25, 1975 | Washington 35, Oregon State 7 | Box score |
| Oct 25, 1975 | Wisconsin 17, Northwestern 14 | Box score |
| Oct 25, 1975 | Yale 20, Cornell 14 | Box score |