| Oct 17, 1975 | Miami 24, Houston 20 | Box score |
| Oct 18, 1975 | 6Alabama 30, 16Tennessee 7 | Box score |
| Oct 18, 1975 | 13Arizona 32, Texas Tech 28 | Box score |
| Oct 18, 1975 | 11Arizona State 33, Colorado State 3 | Box score |
| Oct 18, 1975 | Arkansas State 14, Cincinnati 9 | Box score |
| Oct 18, 1975 | Auburn 31, Georgia Tech 27 | Box score |
| Oct 18, 1975 | Ball State 16, Central Michigan 13 | Box score |
| Oct 18, 1975 | Boston College 17, Navy 3 | Box score |
| Oct 18, 1975 | Bowling Green 35, Kent State 9 | Box score |
| Oct 18, 1975 | Dartmouth 10, Brown 10 | Box score |
| Oct 18, 1975 | California 51, Oregon State 24 | Box score |
| Oct 18, 1975 | The Citadel 44, Davidson 0 | Box score |
| Oct 18, 1975 | Colgate 22, Princeton 21upset | Box score |
| Oct 18, 1975 | 12Colorado 31, 10Missouri 20upset | Box score |
| Oct 18, 1975 | Duke 25, Clemson 21 | Box score |
| Oct 18, 1975 | 14Florida 34, Florida State 8 | Box score |
| Oct 18, 1975 | Furman 21, Holy Cross 14 | Box score |
| Oct 18, 1975 | Georgia 47, Vanderbilt 3 | Box score |
| Oct 18, 1975 | Harvard 34, Cornell 13 | Box score |
| Oct 18, 1975 | Iowa 20, Indiana 10 | Box score |
| Oct 18, 1975 | Kansas 21, Iowa State 10 | Box score |
| Oct 18, 1975 | Long Beach State 47, Fresno State 17 | Box score |
| Oct 18, 1975 | Louisiana 21, Lamar 12 | Box score |
| Oct 18, 1975 | LSU 17, Kentucky 14 | Box score |
| Oct 18, 1975 | 19Maryland 27, Wake Forest 0 | Box score |
| Oct 18, 1975 | McNeese 15, UL Monroe 14upset | Box score |
| Oct 18, 1975 | Memphis 41, Louisville 7 | Box score |
| Oct 18, 1975 | Miami (OH) 17, Ohio 9 | Box score |
| Oct 18, 1975 | 7Michigan 69, Northwestern 0 | Box score |
| Oct 18, 1975 | 17Michigan State 38, Minnesota 15 | Box score |
| Oct 18, 1975 | Mississippi State 15, North Texas 12 | Box score |
| Oct 18, 1975 | 4Nebraska 28, Oklahoma State 20 | Box score |
| Oct 18, 1975 | New Mexico 27, Utah 23 | Box score |
| Oct 18, 1975 | NC State 21, North Carolina 20 | Box score |
| Oct 18, 1975 | Northern Illinois 52, Southern Illinois 12 | Box score |
| Oct 18, 1975 | 15Notre Dame 31, Air Force 30 | Box score |
| Oct 18, 1975 | 1Ohio State 56, Wisconsin 0 | Box score |
| Oct 18, 1975 | 2Oklahoma 25, Kansas State 3 | Box score |
| Oct 18, 1975 | 9Penn State 19, Syracuse 7 | Box score |
| Oct 18, 1975 | Pittsburgh 52, Army 20 | Box score |
| Oct 18, 1975 | Purdue 26, Illinois 24upset | Box score |
| Oct 18, 1975 | Rice 28, SMU 17 | Box score |
| Oct 18, 1975 | Richmond 24, VMI 19 | Box score |
| Oct 18, 1975 | Rutgers 24, William & Mary 0 | Box score |
| Oct 18, 1975 | San Diego State 48, New Mexico State 3 | Box score |
| Oct 18, 1975 | San José State 41, Pacific 13 | Box score |
| Oct 18, 1975 | South Carolina 35, Ole Miss 29 | Box score |
| Oct 18, 1975 | 3USC 17, Oregon 3 | Box score |
| Oct 18, 1975 | Southern Miss 34, Texas–Arlington 7 | Box score |
| Oct 18, 1975 | Stanford 24, Washington 21 | Box score |
| Oct 18, 1975 | 8Texas 24, 20Arkansas 18 | Box score |
| Oct 18, 1975 | 5Texas A&M 14, TCU 6 | Box score |
| Oct 18, 1975 | Toledo 25, Western Michigan 7 | Box score |
| Oct 18, 1975 | Tulane 16, West Virginia 14upset | Box score |
| Oct 18, 1975 | Tulsa 41, Wichita State 10 | Box score |
| Oct 18, 1975 | 18UCLA 37, Washington State 23 | Box score |
| Oct 18, 1975 | Villanova 21, Marshall 14 | Box score |
| Oct 18, 1975 | Virginia Tech 24, Virginia 17 | Box score |
| Oct 18, 1975 | West Texas 24, Drake 6 | Box score |
| Oct 18, 1975 | Wyoming 31, UTEP 14 | Box score |
| Oct 18, 1975 | Yale 34, Columbia 7 | Box score |