| Sep 28, 1968 | Air Force 10, 20Wyoming 3upset | Box score |
| Sep 28, 1968 | 7Alabama 17, Southern Miss 14 | Box score |
| Sep 28, 1968 | Arizona 19, New Mexico 8 | Box score |
| Sep 28, 1968 | 19Arizona State 31, UTEP 19 | Box score |
| Sep 28, 1968 | Arkansas 56, Tulsa 13 | Box score |
| Sep 28, 1968 | Auburn 26, Mississippi State 0 | Box score |
| Sep 28, 1968 | Boston College 49, Navy 15 | Box score |
| Sep 28, 1968 | Bowling Green 20, Dayton 14 | Box score |
| Sep 28, 1968 | California 10, Colorado 0 | Box score |
| Sep 28, 1968 | Cincinnati 17, Xavier 14 | Box score |
| Sep 28, 1968 | Cornell 17, Colgate 0 | Box score |
| Sep 28, 1968 | 5Florida 9, Florida State 3 | Box score |
| Sep 28, 1968 | Georgia 31, Clemson 13 | Box score |
| Sep 28, 1968 | Harvard 27, Holy Cross 20 | Box score |
| Sep 28, 1968 | Iowa State 28, BYU 20upset | Box score |
| Sep 28, 1968 | 12Kansas 38, 13Indiana 20 | Box score |
| Sep 28, 1968 | 14LSU 21, Rice 7 | Box score |
| Sep 28, 1968 | 15Miami 10, Georgia Tech 7 | Box score |
| Sep 28, 1968 | Miami (OH) 28, Western Michigan 0 | Box score |
| Sep 28, 1968 | Michigan 31, Duke 10 | Box score |
| Sep 28, 1968 | Michigan State 28, Baylor 10 | Box score |
| Sep 28, 1968 | Ole Miss 30, Kentucky 14 | Box score |
| Sep 28, 1968 | Missouri 44, Illinois 0 | Box score |
| Sep 28, 1968 | 9Nebraska 17, 17Minnesota 14 | Box score |
| Sep 28, 1968 | North Texas 17, Colorado State 12 | Box score |
| Sep 28, 1968 | Ohio 31, Kent State 7 | Box score |
| Sep 28, 1968 | 11Ohio State 35, SMU 14 | Box score |
| Sep 28, 1968 | Oklahoma 28, NC State 14 | Box score |
| Sep 28, 1968 | 18Oregon State 24, Utah 21 | Box score |
| Sep 28, 1968 | 4Penn State 25, Kansas State 9 | Box score |
| Sep 28, 1968 | 1Purdue 37, 2Notre Dame 22 | Box score |
| Sep 28, 1968 | Richmond 24, Davidson 14 | Box score |
| Sep 28, 1968 | Rutgers 20, Princeton 14upset | Box score |
| Sep 28, 1968 | South Carolina 32, North Carolina 27 | Box score |
| Sep 28, 1968 | 3USC 24, Northwestern 7 | Box score |
| Sep 28, 1968 | Stanford 28, Oregon 12 | Box score |
| Sep 28, 1968 | Syracuse 32, Maryland 14 | Box score |
| Sep 28, 1968 | 16Tennessee 24, Memphis 17 | Box score |
| Sep 28, 1968 | Texas A&M 35, Tulane 3 | Box score |
| Sep 28, 1968 | TCU 28, Iowa 17 | Box score |
| Sep 28, 1968 | Texas Tech 31, 6Texas 22upset | Box score |
| Sep 28, 1968 | Toledo 35, Marshall 12 | Box score |
| Sep 28, 1968 | 8UCLA 31, Washington State 21 | Box score |
| Sep 28, 1968 | Utah State 38, Wichita State 0 | Box score |
| Sep 28, 1968 | Vanderbilt 17, Army 13upset | Box score |
| Sep 28, 1968 | Virginia 47, VMI 0 | Box score |
| Sep 28, 1968 | Virginia Tech 12, William & Mary 0 | Box score |
| Sep 28, 1968 | Washington 21, Wisconsin 17 | Box score |
| Sep 28, 1968 | West Texas 23, Pacific 7 | Box score |
| Sep 28, 1968 | West Virginia 38, Pittsburgh 15 | Box score |