| Sep 20, 1968 | 19Miami 28, Northwestern 7 | Box score |
| Sep 21, 1968 | 7Alabama 14, Virginia Tech 7 | Box score |
| Sep 21, 1968 | Arizona 21, Iowa State 12 | Box score |
| Sep 21, 1968 | Arizona State 55, Wisconsin 7 | Box score |
| Sep 21, 1968 | Arkansas 32, Oklahoma State 15 | Box score |
| Sep 21, 1968 | Army 34, The Citadel 14 | Box score |
| Sep 21, 1968 | BYU 17, Western Michigan 7 | Box score |
| Sep 21, 1968 | Buffalo 21, Kent State 13 | Box score |
| Sep 21, 1968 | California 21, Michigan 7 | Box score |
| Sep 21, 1968 | Texas Tech 10, Cincinnati 10 | Box score |
| Sep 21, 1968 | Wake Forest 20, Clemson 20 | Box score |
| Sep 21, 1968 | Colorado 28, Oregon 7 | Box score |
| Sep 21, 1968 | Duke 14, South Carolina 7 | Box score |
| Sep 21, 1968 | 6Florida 23, Air Force 20 | Box score |
| Sep 21, 1968 | Florida State 24, Maryland 14 | Box score |
| Sep 21, 1968 | Georgia Tech 17, TCU 7 | Box score |
| Sep 21, 1968 | 4Texas 20, 11Houston 20 | Box score |
| Sep 21, 1968 | 15Indiana 40, Baylor 36 | Box score |
| Sep 21, 1968 | Iowa 21, 8Oregon State 20upset | Box score |
| Sep 21, 1968 | Kansas 47, Illinois 7 | Box score |
| Sep 21, 1968 | Kansas State 21, Colorado State 0 | Box score |
| Sep 21, 1968 | Kentucky 12, Missouri 6 | Box score |
| Sep 21, 1968 | 20LSU 13, 13Texas A&M 12upset | Box score |
| Sep 21, 1968 | Michigan State 14, Syracuse 10 | Box score |
| Sep 21, 1968 | Ole Miss 21, Memphis 7 | Box score |
| Sep 21, 1968 | 14Nebraska 31, Utah 0 | Box score |
| Sep 21, 1968 | NC State 38, North Carolina 6 | Box score |
| Sep 21, 1968 | North Texas 47, New Mexico State 20 | Box score |
| Sep 21, 1968 | 3Notre Dame 45, 5Oklahoma 21 | Box score |
| Sep 21, 1968 | Ohio 48, Marshall 8 | Box score |
| Sep 21, 1968 | Pacific 21, Miami (OH) 20upset | Box score |
| Sep 21, 1968 | 10Penn State 31, Navy 6 | Box score |
| Sep 21, 1968 | 1Purdue 44, Virginia 6 | Box score |
| Sep 21, 1968 | Washington 35, Rice 35 | Box score |
| Sep 21, 1968 | 2USC 29, 16Minnesota 20 | Box score |
| Sep 21, 1968 | SMU 37, Auburn 28upset | Box score |
| Sep 21, 1968 | Stanford 68, San José State 20 | Box score |
| Sep 21, 1968 | UTEP 44, New Mexico 15 | Box score |
| Sep 21, 1968 | Toledo 45, Villanova 21 | Box score |
| Sep 21, 1968 | 16UCLA 63, Pittsburgh 7 | Box score |
| Sep 21, 1968 | Vanderbilt 25, VMI 12 | Box score |
| Sep 21, 1968 | West Texas 26, Wichita State 0 | Box score |
| Sep 21, 1968 | West Virginia 17, Richmond 0 | Box score |
| Sep 21, 1968 | William & Mary 14, East Carolina 0 | Box score |
| Sep 21, 1968 | Wyoming 48, Utah State 3 | Box score |