| Sep 23, 1966 | Houston 21, Washington State 7 | Box score |
| Sep 24, 1966 | Air Force 10, Washington 0upset | Box score |
| Sep 24, 1966 | 6Arkansas 27, Tulsa 8 | Box score |
| Sep 24, 1966 | Army 14, Holy Cross 0 | Box score |
| Sep 24, 1966 | BYU 19, San José State 9 | Box score |
| Sep 24, 1966 | The Citadel 24, Richmond 6 | Box score |
| Sep 24, 1966 | Clemson 40, Virginia 35 | Box score |
| Sep 24, 1966 | Colgate 38, Columbia 0 | Box score |
| Sep 24, 1966 | Colorado 13, 10Baylor 7upset | Box score |
| Sep 24, 1966 | Cornell 28, Buffalo 21 | Box score |
| Sep 24, 1966 | Dayton 23, Cincinnati 7upset | Box score |
| Sep 24, 1966 | Duke 14, Pittsburgh 7 | Box score |
| Sep 24, 1966 | Florida 28, Mississippi State 7 | Box score |
| Sep 24, 1966 | Florida State 23, Miami 20upset | Box score |
| Sep 24, 1966 | Georgia 43, VMI 7 | Box score |
| Sep 24, 1966 | Georgia Tech 42, Vanderbilt 0 | Box score |
| Sep 24, 1966 | Indiana 26, Northwestern 14upset | Box score |
| Sep 24, 1966 | Kansas 35, Arizona 13 | Box score |
| Sep 24, 1966 | Maryland 34, Wake Forest 7 | Box score |
| Sep 24, 1966 | Memphis 16, South Carolina 7 | Box score |
| Sep 24, 1966 | Miami (OH) 27, Xavier 3 | Box score |
| Sep 24, 1966 | 9Michigan 17, California 7 | Box score |
| Sep 24, 1966 | 1Michigan State 42, Penn State 8 | Box score |
| Sep 24, 1966 | Minnesota 35, Stanford 21 | Box score |
| Sep 24, 1966 | Ole Miss 17, Kentucky 0 | Box score |
| Sep 24, 1966 | Missouri 21, Illinois 14 | Box score |
| Sep 24, 1966 | 4Nebraska 28, Utah State 7 | Box score |
| Sep 24, 1966 | New Mexico 28, Kansas State 8 | Box score |
| Sep 24, 1966 | North Carolina 10, NC State 7 | Box score |
| Sep 24, 1966 | North Texas 12, UTEP 9 | Box score |
| Sep 24, 1966 | 8Notre Dame 26, 7Purdue 14upset | Box score |
| Sep 24, 1966 | Ohio 23, Boston College 14upset | Box score |
| Sep 24, 1966 | Ohio State 14, TCU 7 | Box score |
| Sep 24, 1966 | Oklahoma 33, Iowa State 11 | Box score |
| Sep 24, 1966 | Oregon State 17, Iowa 3 | Box score |
| Sep 24, 1966 | Princeton 16, Rutgers 12 | Box score |
| Sep 24, 1966 | Rice 17, LSU 15upset | Box score |
| Sep 24, 1966 | 5USC 38, Wisconsin 3 | Box score |
| Sep 24, 1966 | SMU 21, Navy 3 | Box score |
| Sep 24, 1966 | Tampa 20, Bowling Green 13upset | Box score |
| Sep 24, 1966 | Tennessee 28, Auburn 0 | Box score |
| Sep 24, 1966 | Texas 31, Texas Tech 21 | Box score |
| Sep 24, 1966 | Tulane 21, Texas A&M 13 | Box score |
| Sep 24, 1966 | 2UCLA 31, Syracuse 12 | Box score |
| Sep 24, 1966 | Utah 17, Oregon 14 | Box score |
| Sep 24, 1966 | Villanova 20, Toledo 11 | Box score |
| Sep 24, 1966 | Virginia Tech 49, George Washington 0 | Box score |
| Sep 24, 1966 | West Texas 49, Pacific 7 | Box score |
| Sep 24, 1966 | West Virginia 24, William & Mary 13 | Box score |
| Sep 24, 1966 | Wyoming 23, Arizona State 6 | Box score |