| Oct 15, 1965 | Cincinnati 13, George Washington 3 | Box score |
| Oct 16, 1965 | Air Force 18, Oregon 18 | Box score |
| Oct 16, 1965 | 3Arkansas 27, 1Texas 24upset | Box score |
| Oct 16, 1965 | Arkansas State 14, The Citadel 0upset | Box score |
| Oct 16, 1965 | Army 23, Rutgers 6 | Box score |
| Oct 16, 1965 | Bowling Green 21, Toledo 14 | Box score |
| Oct 16, 1965 | Buffalo 24, Richmond 0 | Box score |
| Oct 16, 1965 | California 16, Washington 12 | Box score |
| Oct 16, 1965 | Clemson 3, Duke 2upset | Box score |
| Oct 16, 1965 | Columbia 21, Yale 7 | Box score |
| Oct 16, 1965 | Dartmouth 35, Brown 9 | Box score |
| Oct 16, 1965 | East Carolina 34, Louisville 20 | Box score |
| Oct 16, 1965 | 9Florida 28, NC State 6 | Box score |
| Oct 16, 1965 | Florida State 10, 5Georgia 3upset | Box score |
| Oct 16, 1965 | Georgia Tech 23, Auburn 14 | Box score |
| Oct 16, 1965 | Cornell 3, Harvard 3 | Box score |
| Oct 16, 1965 | Illinois 34, Indiana 13 | Box score |
| Oct 16, 1965 | Colorado 10, Iowa State 10 | Box score |
| Oct 16, 1965 | Western Michigan 10, Kent State 10 | Box score |
| Oct 16, 1965 | LSU 31, Kentucky 21 | Box score |
| Oct 16, 1965 | Memphis 33, 10Mississippi State 13upset | Box score |
| Oct 16, 1965 | Miami 44, Houston 12 | Box score |
| Oct 16, 1965 | Miami (OH) 28, Marshall 7 | Box score |
| Oct 16, 1965 | 4Michigan State 32, Ohio State 7 | Box score |
| Oct 16, 1965 | Minnesota 14, Iowa 3 | Box score |
| Oct 16, 1965 | Ole Miss 24, Tulane 7 | Box score |
| Oct 16, 1965 | Navy 12, Pittsburgh 0 | Box score |
| Oct 16, 1965 | 2Nebraska 41, Kansas State 0 | Box score |
| Oct 16, 1965 | New Mexico 13, Utah 10 | Box score |
| Oct 16, 1965 | New Mexico State 45, Wichita State 20 | Box score |
| Oct 16, 1965 | North Carolina 12, Maryland 10 | Box score |
| Oct 16, 1965 | Oklahoma 21, Kansas 7 | Box score |
| Oct 16, 1965 | Oregon State 16, Idaho 14 | Box score |
| Oct 16, 1965 | Princeton 27, Colgate 0 | Box score |
| Oct 16, 1965 | 7Purdue 17, Michigan 15 | Box score |
| Oct 16, 1965 | Quantico Marines 10, Dayton 0upset | Box score |
| Oct 16, 1965 | San José State 21, Arizona State 14 | Box score |
| Oct 16, 1965 | South Carolina 38, Wake Forest 7 | Box score |
| Oct 16, 1965 | 6USC 14, Stanford 0 | Box score |
| Oct 16, 1965 | SMU 17, Rice 14upset | Box score |
| Oct 16, 1965 | Southern Miss 3, VMI 0 | Box score |
| Oct 16, 1965 | Syracuse 28, Penn State 21 | Box score |
| Oct 16, 1965 | Tennessee 7, Alabama 7 | Box score |
| Oct 16, 1965 | TCU 17, Texas A&M 9 | Box score |
| Oct 16, 1965 | Texas Tech 17, Oklahoma State 14 | Box score |
| Oct 16, 1965 | Tulsa 27, North Texas 20 | Box score |
| Oct 16, 1965 | Missouri 14, UCLA 14 | Box score |
| Oct 16, 1965 | Vanderbilt 21, Virginia Tech 10upset | Box score |
| Oct 16, 1965 | Virginia 41, West Virginia 0 | Box score |
| Oct 16, 1965 | Washington State 21, Arizona 3 | Box score |
| Oct 16, 1965 | West Texas 15, Colorado State 12 | Box score |
| Oct 16, 1965 | Wisconsin 21, Northwestern 7upset | Box score |
| Oct 16, 1965 | Wyoming 38, UTEP 14 | Box score |
| Oct 16, 1965 | Xavier 21, Ohio 19 | Box score |