| Oct 8, 1965 | BYU 34, San José State 7 | Box score |
| Oct 9, 1965 | Alabama 22, Vanderbilt 7 | Box score |
| Oct 9, 1965 | Arizona State 8, Wichita State 6 | Box score |
| Oct 9, 1965 | 3Arkansas 38, Baylor 7 | Box score |
| Oct 9, 1965 | Bowling Green 21, Western Michigan 17 | Box score |
| Oct 9, 1965 | California 24, Air Force 7 | Box score |
| Oct 9, 1965 | Colgate 7, Holy Cross 3 | Box score |
| Oct 9, 1965 | Colorado 34, Oklahoma State 11 | Box score |
| Oct 9, 1965 | Dartmouth 24, Pennsylvania 19 | Box score |
| Oct 9, 1965 | Duke 21, Pittsburgh 13 | Box score |
| Oct 9, 1965 | East Carolina 34, Richmond 13 | Box score |
| Oct 9, 1965 | 10Florida 17, Ole Miss 0 | Box score |
| Oct 9, 1965 | 4Georgia 23, Clemson 9 | Box score |
| Oct 9, 1965 | Georgia Tech 13, Tulane 10 | Box score |
| Oct 9, 1965 | Harvard 21, Columbia 6 | Box score |
| Oct 9, 1965 | Iowa State 21, Kansas 7 | Box score |
| Oct 9, 1965 | Kent State 24, Miami (OH) 13 | Box score |
| Oct 9, 1965 | Kentucky 26, Florida State 24 | Box score |
| Oct 9, 1965 | LSU 34, Miami 27 | Box score |
| Oct 9, 1965 | Louisville 34, Dayton 0 | Box score |
| Oct 9, 1965 | Marshall 10, Quantico Marines 9 | Box score |
| Oct 9, 1965 | Maryland 10, Wake Forest 7 | Box score |
| Oct 9, 1965 | 5Michigan State 24, Michigan 7 | Box score |
| Oct 9, 1965 | Minnesota 42, Indiana 18 | Box score |
| Oct 9, 1965 | 9Mississippi State 27, Southern Miss 9 | Box score |
| Oct 9, 1965 | Missouri 28, Kansas State 6 | Box score |
| Oct 9, 1965 | Navy 42, William & Mary 14 | Box score |
| Oct 9, 1965 | 2Nebraska 37, Wisconsin 0 | Box score |
| Oct 9, 1965 | New Mexico 24, Arizona 2upset | Box score |
| Oct 9, 1965 | New Mexico State 14, Pacific 6 | Box score |
| Oct 9, 1965 | North Carolina 10, NC State 7 | Box score |
| Oct 9, 1965 | Northwestern 15, Oregon State 7 | Box score |
| Oct 9, 1965 | 7Notre Dame 17, Army 0 | Box score |
| Oct 9, 1965 | Ohio State 28, Illinois 14 | Box score |
| Oct 9, 1965 | Penn State 17, Boston College 0 | Box score |
| Oct 9, 1965 | Princeton 36, Cornell 27 | Box score |
| Oct 9, 1965 | 6Purdue 17, Iowa 14 | Box score |
| Oct 9, 1965 | 8USC 34, Washington 0 | Box score |
| Oct 9, 1965 | Stanford 17, Oregon 14 | Box score |
| Oct 9, 1965 | Tennessee 24, South Carolina 3 | Box score |
| Oct 9, 1965 | 1Texas 19, Oklahoma 0 | Box score |
| Oct 9, 1965 | Texas A&M 10, Houston 7 | Box score |
| Oct 9, 1965 | Texas Tech 28, TCU 24 | Box score |
| Oct 9, 1965 | UTEP 35, Colorado State 10 | Box score |
| Oct 9, 1965 | Toledo 21, Ohio 7 | Box score |
| Oct 9, 1965 | Tulsa 32, Memphis 28 | Box score |
| Oct 9, 1965 | UCLA 24, Syracuse 14 | Box score |
| Oct 9, 1965 | Utah 42, Wyoming 3 | Box score |
| Oct 9, 1965 | Utah State 30, Idaho 19 | Box score |
| Oct 9, 1965 | Virginia 14, VMI 10 | Box score |
| Oct 9, 1965 | Virginia Tech 17, George Washington 12 | Box score |
| Oct 9, 1965 | Washington State 24, Villanova 14 | Box score |
| Oct 9, 1965 | West Virginia 25, The Citadel 2 | Box score |
| Oct 9, 1965 | Xavier 14, Cincinnati 3upset | Box score |
| Oct 9, 1965 | Yale 3, Brown 0 | Box score |