| Sep 24, 1965 | BYU 21, Kansas State 3 | Box score |
| Sep 24, 1965 | Houston 21, Cincinnati 6upset | Box score |
| Sep 25, 1965 | Alabama 27, Tulane 0 | Box score |
| Sep 25, 1965 | Arizona 23, Kansas 15 | Box score |
| Sep 25, 1965 | 5Arkansas 20, Tulsa 12 | Box score |
| Sep 25, 1965 | Army 21, VMI 7 | Box score |
| Sep 25, 1965 | Tennessee 13, Auburn 13 | Box score |
| Sep 25, 1965 | Baylor 17, Washington 14 | Box score |
| Sep 25, 1965 | Boston College 28, Villanova 0 | Box score |
| Sep 25, 1965 | Clemson 20, Virginia 14 | Box score |
| Sep 25, 1965 | Cornell 0, Colgate 0 | Box score |
| Sep 25, 1965 | Duke 20, South Carolina 15 | Box score |
| Sep 25, 1965 | George Washington 30, The Citadel 7 | Box score |
| Sep 25, 1965 | Georgia 24, Vanderbilt 10 | Box score |
| Sep 25, 1965 | Harvard 17, Holy Cross 7 | Box score |
| Sep 25, 1965 | Idaho 17, San José State 7 | Box score |
| Sep 25, 1965 | Illinois 42, SMU 0 | Box score |
| Sep 25, 1965 | Iowa 27, Oregon State 7upset | Box score |
| Sep 25, 1965 | Iowa State 38, Pacific 13 | Box score |
| Sep 25, 1965 | Kent State 14, Dayton 6 | Box score |
| Sep 25, 1965 | 10Kentucky 16, Ole Miss 7 | Box score |
| Sep 25, 1965 | 7LSU 42, Rice 14 | Box score |
| Sep 25, 1965 | Maryland 24, Ohio 7 | Box score |
| Sep 25, 1965 | Miami 24, 9Syracuse 0upset | Box score |
| Sep 25, 1965 | 4Michigan 10, California 7 | Box score |
| Sep 25, 1965 | Michigan State 23, Penn State 0 | Box score |
| Sep 25, 1965 | Mississippi State 18, 8Florida 13upset | Box score |
| Sep 25, 1965 | Missouri 13, Oklahoma State 0 | Box score |
| Sep 25, 1965 | Stanford 7, Navy 7 | Box score |
| Sep 25, 1965 | 2Nebraska 27, Air Force 17 | Box score |
| Sep 25, 1965 | North Carolina 14, Ohio State 3 | Box score |
| Sep 25, 1965 | NC State 13, Wake Forest 11 | Box score |
| Sep 25, 1965 | Northwestern 20, Indiana 0 | Box score |
| Sep 25, 1965 | Oregon 31, Utah 14 | Box score |
| Sep 25, 1965 | Pittsburgh 13, Oklahoma 9 | Box score |
| Sep 25, 1965 | Princeton 32, Rutgers 6 | Box score |
| Sep 25, 1965 | 6Purdue 25, 1Notre Dame 21upset | Box score |
| Sep 25, 1965 | USC 26, Wisconsin 6 | Box score |
| Sep 25, 1965 | Southern Miss 21, Memphis 16 | Box score |
| Sep 25, 1965 | 3Texas 33, Texas Tech 7 | Box score |
| Sep 25, 1965 | Texas A&M 14, Georgia Tech 10upset | Box score |
| Sep 25, 1965 | TCU 7, Florida State 3 | Box score |
| Sep 25, 1965 | UTEP 35, New Mexico 14upset | Box score |
| Sep 25, 1965 | Toledo 9, Quantico Marines 0 | Box score |
| Sep 25, 1965 | Utah State 13, Arizona State 0 | Box score |
| Sep 25, 1965 | Virginia Tech 25, Richmond 7 | Box score |
| Sep 25, 1965 | Washington State 14, Minnesota 13upset | Box score |
| Sep 25, 1965 | West Texas 34, Bowling Green 0 | Box score |
| Sep 25, 1965 | West Virginia 34, William & Mary 14 | Box score |
| Sep 25, 1965 | Wyoming 33, Colorado State 14 | Box score |
| Sep 25, 1965 | Xavier 29, Miami (OH) 28 | Box score |