1965: Week 2
55 games. One ranked team lost, to an unranked team. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Sep 17, 1965 | 7USC 20, Minnesota 20 | Box score |
| Sep 17, 1965 | Stanford 26, San José State 6 | Box score |
| Sep 18, 1965 | Arizona 16, Utah 9upset | Box score |
| Sep 18, 1965 | 6Arkansas 28, Oklahoma State 14 | Box score |
| Sep 18, 1965 | Baylor 14, Auburn 8 | Box score |
| Sep 18, 1965 | Boston College 18, Buffalo 6 | Box score |
| Sep 18, 1965 | BYU 24, Arizona State 6upset | Box score |
| Sep 18, 1965 | Cincinnati 28, Dayton 0 | Box score |
| Sep 18, 1965 | Clemson 21, NC State 7 | Box score |
| Sep 18, 1965 | Wisconsin 0, Colorado 0 | Box score |
| Sep 18, 1965 | Duke 21, Virginia 7 | Box score |
| Sep 18, 1965 | Florida 24, Northwestern 14 | Box score |
| Sep 18, 1965 | Georgia 18, 5Alabama 17upset | Box score |
| Sep 18, 1965 | Vanderbilt 10, Georgia Tech 10 | Box score |
| Sep 18, 1965 | Indiana 19, Kansas State 7 | Box score |
| Sep 18, 1965 | Iowa State 21, Drake 0 | Box score |
| Sep 18, 1965 | Kentucky 7, Missouri 0upset | Box score |
| Sep 18, 1965 | 8LSU 10, Texas A&M 0 | Box score |
| Sep 18, 1965 | 4Michigan 31, North Carolina 24 | Box score |
| Sep 18, 1965 | Michigan State 13, UCLA 3 | Box score |
| Sep 18, 1965 | Ole Miss 34, Memphis 14 | Box score |
| Sep 18, 1965 | Mississippi State 36, Houston 0 | Box score |
| Sep 18, 1965 | 1Nebraska 34, TCU 14 | Box score |
| Sep 18, 1965 | 3Notre Dame 48, California 6 | Box score |
| Sep 18, 1965 | Oregon 17, Pittsburgh 15 | Box score |
| Sep 18, 1965 | Oregon State 12, Illinois 10 | Box score |
| Sep 18, 1965 | 9Purdue 38, Miami (OH) 0 | Box score |
| Sep 18, 1965 | South Carolina 13, The Citadel 3 | Box score |
| Sep 18, 1965 | SMU 7, Miami 3upset | Box score |
| Sep 18, 1965 | Syracuse 14, Navy 6 | Box score |
| Sep 18, 1965 | Tennessee 21, Army 0 | Box score |
| Sep 18, 1965 | 2Texas 31, Tulane 0 | Box score |
| Sep 18, 1965 | Texas Tech 26, Kansas 7 | Box score |
| Sep 18, 1965 | UTEP 61, North Texas 15 | Box score |
| Sep 18, 1965 | Toledo 9, Villanova 7upset | Box score |
| Sep 18, 1965 | Virginia Tech 12, Wake Forest 3 | Box score |
| Sep 18, 1965 | Washington 14, Idaho 9 | Box score |
| Sep 18, 1965 | Washington State 7, Iowa 0upset | Box score |
| Sep 18, 1965 | West Texas 7, Ohio 0upset | Box score |
| Sep 18, 1965 | Western Michigan 17, Louisville 13 | Box score |
| Sep 18, 1965 | William & Mary 32, VMI 21 | Box score |
| Sep 18, 1965 | Wyoming 31, Air Force 14 | Box score |
| Sep 18, 1965 | Xavier 21, Kent State 14 | Box score |
| Sep 19, 1965 | West Virginia 56, Richmond 0 | Box score |
Everyone else
| Sep 18, 1965 | Bowling Green 21, Cal State Los Angeles 0 | Box score |
| Sep 18, 1965 | Colgate 40, Lafayette 0 | Box score |
| Sep 18, 1965 | Colorado State 54, Hawai’i 6 | Box score |
| Sep 18, 1965 | Davidson 35, Presbyterian 0 | Box score |
| Sep 18, 1965 | Furman 51, Frederick 14 | Box score |
| Sep 18, 1965 | George Washington 21, Temple 13 | Box score |
| Sep 18, 1965 | Marshall 22, Morehead State 12 | Box score |
| Sep 18, 1965 | New Mexico State 27, Texas–Arlington 10 | Box score |
| Sep 18, 1965 | Rice 14, Louisiana Tech 0 | Box score |
| Sep 18, 1965 | San Diego State 46, Pacific 6 | Box score |
| Sep 18, 1965 | Southern Miss 15, SE Louisiana 0 | Box score |