| Oct 14, 1960 | Miami 21, South Carolina 6 | Box score |
| Oct 15, 1960 | 18Arizona State 31, BYU 0 | Box score |
| Oct 15, 1960 | Arkansas 24, 11Texas 23upset | Box score |
| Oct 15, 1960 | Auburn 9, 19Georgia Tech 7upset | Box score |
| Oct 15, 1960 | 7Baylor 14, Texas Tech 7 | Box score |
| Oct 15, 1960 | The Citadel 24, Richmond 12 | Box score |
| Oct 15, 1960 | Colorado 21, Iowa State 6 | Box score |
| Oct 15, 1960 | Detroit Mercy 19, Boston College 17 | Box score |
| Oct 15, 1960 | Duke 17, NC State 13 | Box score |
| Oct 15, 1960 | Florida 12, Vanderbilt 0 | Box score |
| Oct 15, 1960 | Boston University 0, George Washington 0 | Box score |
| Oct 15, 1960 | Georgia 20, Mississippi State 17 | Box score |
| Oct 15, 1960 | Harvard 8, Columbia 7 | Box score |
| Oct 15, 1960 | Holy Cross 9, Dartmouth 8upset | Box score |
| Oct 15, 1960 | Houston 12, Oklahoma State 7 | Box score |
| Oct 15, 1960 | Indiana 34, Marquette 8 | Box score |
| Oct 15, 1960 | 2Iowa 28, 12Wisconsin 21 | Box score |
| Oct 15, 1960 | Kentucky 3, LSU 0 | Box score |
| Oct 15, 1960 | Louisville 36, Dayton 0 | Box score |
| Oct 15, 1960 | Maryland 19, 8Clemson 17upset | Box score |
| Oct 15, 1960 | Memphis 42, Hardin Simmons 7 | Box score |
| Oct 15, 1960 | Miami (OH) 17, Villanova 7 | Box score |
| Oct 15, 1960 | Michigan 14, Northwestern 7 | Box score |
| Oct 15, 1960 | 14Michigan State 21, Notre Dame 0 | Box score |
| Oct 15, 1960 | 10Minnesota 21, Illinois 10 | Box score |
| Oct 15, 1960 | 1Ole Miss 26, Tulane 13 | Box score |
| Oct 15, 1960 | 6Missouri 45, Kansas State 0 | Box score |
| Oct 15, 1960 | Montana 26, Denver 12upset | Box score |
| Oct 15, 1960 | 5Navy 35, Air Force 3 | Box score |
| Oct 15, 1960 | Nebraska 14, Army 9upset | Box score |
| Oct 15, 1960 | Ohio 6, Xavier 0 | Box score |
| Oct 15, 1960 | 9Kansas 13, Oklahoma 13 | Box score |
| Oct 15, 1960 | Oregon 21, Washington State 12 | Box score |
| Oct 15, 1960 | 17Oregon State 28, Idaho 8 | Box score |
| Oct 15, 1960 | Pennsylvania 36, Brown 7 | Box score |
| Oct 15, 1960 | Pittsburgh 42, West Virginia 0 | Box score |
| Oct 15, 1960 | Princeton 36, Colgate 26 | Box score |
| Oct 15, 1960 | Purdue 24, 3Ohio State 21upset | Box score |
| Oct 15, 1960 | Rice 47, SMU 0 | Box score |
| Oct 15, 1960 | San José State 34, Stanford 20 | Box score |
| Oct 15, 1960 | USC 27, California 10 | Box score |
| Oct 15, 1960 | Southern Miss 15, Florida State 13 | Box score |
| Oct 15, 1960 | 4Syracuse 21, 20Penn State 15 | Box score |
| Oct 15, 1960 | Tennessee 20, 15Alabama 7upset | Box score |
| Oct 15, 1960 | Texas A&M 14, TCU 14 | Box score |
| Oct 15, 1960 | Tulsa 17, Arizona 16 | Box score |
| Oct 15, 1960 | Utah State 46, New Mexico 7 | Box score |
| Oct 15, 1960 | VMI 30, Virginia 16 | Box score |
| Oct 15, 1960 | Virginia Tech 27, William & Mary 0 | Box score |
| Oct 15, 1960 | Wake Forest 13, North Carolina 12upset | Box score |
| Oct 15, 1960 | 13Washington 10, 15UCLA 8 | Box score |
| Oct 15, 1960 | West Texas 14, North Texas 6 | Box score |
| Oct 15, 1960 | Wichita State 25, Cincinnati 8upset | Box score |
| Oct 15, 1960 | Wyoming 40, Colorado State 8 | Box score |
| Oct 15, 1960 | Yale 22, Cornell 6 | Box score |