| Oct 7, 1960 | Detroit Mercy 14, Cincinnati 0 | Box score |
| Oct 7, 1960 | USC 10, Georgia 3 | Box score |
| Oct 7, 1960 | Utah 17, BYU 0 | Box score |
| Oct 7, 1960 | VMI 34, George Washington 10 | Box score |
| Oct 8, 1960 | Arizona State 28, Hardin Simmons 0 | Box score |
| Oct 8, 1960 | 20Baylor 28, 9Arkansas 14upset | Box score |
| Oct 8, 1960 | 8Clemson 21, Virginia 7 | Box score |
| Oct 8, 1960 | Colorado 35, Arizona 16 | Box score |
| Oct 8, 1960 | Colorado State 30, Drake 3 | Box score |
| Oct 8, 1960 | Cornell 12, Harvard 0 | Box score |
| Oct 8, 1960 | Dartmouth 20, Brown 0 | Box score |
| Oct 8, 1960 | The Citadel 0, Florida State 0 | Box score |
| Oct 8, 1960 | Georgia Tech 6, LSU 2 | Box score |
| Oct 8, 1960 | Houston 17, Texas A&M 0 | Box score |
| Oct 8, 1960 | 3Iowa 27, 13Michigan State 15 | Box score |
| Oct 8, 1960 | 10Kansas 28, Iowa State 14 | Box score |
| Oct 8, 1960 | Kentucky 55, Marshall 0 | Box score |
| Oct 8, 1960 | Marquette 13, Boston College 12 | Box score |
| Oct 8, 1960 | Memphis 44, North Texas 0upset | Box score |
| Oct 8, 1960 | Michigan 31, Duke 6 | Box score |
| Oct 8, 1960 | 14Minnesota 7, Northwestern 0 | Box score |
| Oct 8, 1960 | 2Ole Miss 26, Vanderbilt 0 | Box score |
| Oct 8, 1960 | 11Missouri 34, Air Force 8 | Box score |
| Oct 8, 1960 | 6Navy 26, SMU 7 | Box score |
| Oct 8, 1960 | Nebraska 17, Kansas State 7 | Box score |
| Oct 8, 1960 | New Mexico State 34, New Mexico 0 | Box score |
| Oct 8, 1960 | North Carolina 12, Notre Dame 7 | Box score |
| Oct 8, 1960 | NC State 13, Maryland 10 | Box score |
| Oct 8, 1960 | Ohio 36, Boston University 6 | Box score |
| Oct 8, 1960 | 5Ohio State 34, 4Illinois 7upset | Box score |
| Oct 8, 1960 | Oklahoma State 28, Tulsa 7 | Box score |
| Oct 8, 1960 | Oregon 33, San José State 0 | Box score |
| Oct 8, 1960 | Oregon State 20, Indiana 6 | Box score |
| Oct 8, 1960 | Pacific 24, Villanova 7 | Box score |
| Oct 8, 1960 | Penn State 27, 18Army 16upset | Box score |
| Oct 8, 1960 | Pittsburgh 17, Miami 6 | Box score |
| Oct 8, 1960 | Princeton 21, Pennsylvania 0 | Box score |
| Oct 8, 1960 | Rice 10, 18Florida 0upset | Box score |
| Oct 8, 1960 | West Virginia 6, Richmond 6 | Box score |
| Oct 8, 1960 | Rutgers 49, Colgate 12 | Box score |
| Oct 8, 1960 | 1Syracuse 15, Holy Cross 6 | Box score |
| Oct 8, 1960 | 15Texas 24, Oklahoma 0 | Box score |
| Oct 8, 1960 | TCU 21, Texas Tech 7 | Box score |
| Oct 8, 1960 | UTEP 6, West Texas 3 | Box score |
| Oct 8, 1960 | Utah State 33, Idaho 6 | Box score |
| Oct 8, 1960 | Virginia Tech 22, Wake Forest 13 | Box score |
| Oct 8, 1960 | 12Washington 29, Stanford 10 | Box score |
| Oct 8, 1960 | California 21, Washington State 21 | Box score |
| Oct 8, 1960 | Wisconsin 24, 7Purdue 13upset | Box score |
| Oct 8, 1960 | Wyoming 41, Denver 2 | Box score |
| Oct 8, 1960 | Xavier 18, Dayton 12 | Box score |
| Oct 8, 1960 | Yale 30, Columbia 8 | Box score |