1959: Week 2
43 games. One ranked team lost. One game matched two ranked teams. Winners are listed first; numbers before names are AP ranks going in.
The week in review
Upsets
A ranked team beaten as the betting favorite, or, where no line is on file, by an unranked or lower-ranked team.
FBS vs. FBS
| Sep 18, 1959 | Detroit Mercy 38, George Washington 6 | Box score |
| Sep 18, 1959 | Florida 30, Tulane 0 | Box score |
| Sep 18, 1959 | UCLA 0, 11Purdue 0 | Box score |
| Sep 18, 1959 | San José State 14, Denver 13 | Box score |
| Sep 19, 1959 | Arizona State 43, West Texas 22 | Box score |
| Sep 19, 1959 | Arkansas 28, Tulsa 0 | Box score |
| Sep 19, 1959 | BYU 18, Arizona 14 | Box score |
| Sep 19, 1959 | California 20, Washington State 6upset | Box score |
| Sep 19, 1959 | Cincinnati 22, Oklahoma State 9 | Box score |
| Sep 19, 1959 | 18Clemson 20, 12North Carolina 18upset | Box score |
| Sep 19, 1959 | Colorado State 9, Pacific 6 | Box score |
| Sep 19, 1959 | Dayton 6, Richmond 3 | Box score |
| Sep 19, 1959 | Georgia 17, Alabama 3 | Box score |
| Sep 19, 1959 | Georgia Tech 14, Kentucky 12 | Box score |
| Sep 19, 1959 | Iowa State 41, Drake 0 | Box score |
| Sep 19, 1959 | 1LSU 26, Rice 3 | Box score |
| Sep 19, 1959 | Maryland 27, West Virginia 7 | Box score |
| Sep 19, 1959 | 8Ole Miss 16, Houston 0 | Box score |
| Sep 19, 1959 | Navy 24, Boston College 8 | Box score |
| Sep 19, 1959 | New Mexico State 29, New Mexico 12upset | Box score |
| Sep 19, 1959 | NC State 15, Virginia Tech 13 | Box score |
| Sep 19, 1959 | North Texas 46, Hardin Simmons 24 | Box score |
| Sep 19, 1959 | Oregon 28, Stanford 27 | Box score |
| Sep 19, 1959 | Penn State 19, Missouri 8 | Box score |
| Sep 19, 1959 | Pittsburgh 21, Marquette 15 | Box score |
| Sep 19, 1959 | 14South Carolina 12, Duke 7 | Box score |
| Sep 19, 1959 | USC 27, Oregon State 6 | Box score |
| Sep 19, 1959 | 17Texas 20, Nebraska 0 | Box score |
| Sep 19, 1959 | 13TCU 14, Kansas 7 | Box score |
| Sep 19, 1959 | Texas Tech 20, Texas A&M 14 | Box score |
| Sep 19, 1959 | Utah State 14, Idaho 0 | Box score |
| Sep 19, 1959 | VMI 46, Marshall 0 | Box score |
| Sep 19, 1959 | Wake Forest 22, Florida State 20upset | Box score |
| Sep 19, 1959 | Washington 21, Colorado 12upset | Box score |
| Sep 19, 1959 | Wichita State 19, Kansas State 0 | Box score |
| Sep 19, 1959 | William & Mary 37, Virginia 0 | Box score |
| Sep 19, 1959 | Wyoming 58, Montana 0 | Box score |
| Sep 19, 1959 | Xavier 28, Louisville 13upset | Box score |
Everyone else
| Sep 19, 1959 | The Citadel 48, Newberry 0 | Box score |
| Sep 19, 1959 | Davidson 42, Catawba 6 | Box score |
| Sep 19, 1959 | Presbyterian 24, Furman 23 | Box score |
| Sep 19, 1959 | UTEP 43, University of Mexico 8 | Box score |
| Sep 19, 1959 | West Chester 13, Villanova 7upset | Box score |