| Oct 22, 1942 | Clemson 18, South Carolina 6 | Box score |
| Oct 23, 1942 | Auburn 14, Villanova 6 | Box score |
| Oct 23, 1942 | North Carolina Pre-Flight 34, Temple 0 | Box score |
| Oct 23, 1942 | Tulsa 41, Saint Louis 0 | Box score |
| Oct 24, 1942 | 3Alabama 14, Kentucky 0 | Box score |
| Oct 24, 1942 | Arkansas 7, Ole Miss 6 | Box score |
| Oct 24, 1942 | 11Army 14, Harvard 0 | Box score |
| Oct 24, 1942 | Baylor 6, Texas A&M 0 | Box score |
| Oct 24, 1942 | California 19, Washington 6upset | Box score |
| Oct 24, 1942 | Colorado 34, Colorado State 7 | Box score |
| Oct 24, 1942 | Creighton 33, Drake 14 | Box score |
| Oct 24, 1942 | Duke 28, Pittsburgh 0 | Box score |
| Oct 24, 1942 | 2Georgia 35, Cincinnati 13 | Box score |
| Oct 24, 1942 | 6Georgia Tech 21, Navy 0 | Box score |
| Oct 24, 1942 | Hardin Simmons 21, Arizona State 0 | Box score |
| Oct 24, 1942 | Holy Cross 28, NC State 0 | Box score |
| Oct 24, 1942 | Iowa 14, Indiana 13upset | Box score |
| Oct 24, 1942 | Kansas 19, Kansas State 7 | Box score |
| Oct 24, 1942 | LSU 34, Georgia Pre-Flight 0 | Box score |
| Oct 24, 1942 | Manhattan 10, Duquesne 7upset | Box score |
| Oct 24, 1942 | Marquette 39, Arizona 0 | Box score |
| Oct 24, 1942 | Michigan State 14, Great Lakes Navy 0 | Box score |
| Oct 24, 1942 | 13Minnesota 16, 4Michigan 14upset | Box score |
| Oct 24, 1942 | 16Mississippi State 26, Florida 12 | Box score |
| Oct 24, 1942 | Missouri 45, Iowa State 6 | Box score |
| Oct 24, 1942 | Nebraska 7, Oklahoma 0upset | Box score |
| Oct 24, 1942 | 8Notre Dame 21, 5Illinois 14upset | Box score |
| Oct 24, 1942 | 1Ohio State 20, Northwestern 6 | Box score |
| Oct 24, 1942 | Oklahoma State 40, Washington St. Louis 7 | Box score |
| Oct 24, 1942 | Penn State 13, Colgate 10 | Box score |
| Oct 24, 1942 | 17Pennsylvania 42, Columbia 12 | Box score |
| Oct 24, 1942 | Princeton 32, Brown 13 | Box score |
| Oct 24, 1942 | Saint Mary’s (CA) 13, Loyola Marymount 0 | Box score |
| Oct 24, 1942 | Stanford 14, USC 6 | Box score |
| Oct 24, 1942 | 15Texas 12, Rice 7 | Box score |
| Oct 24, 1942 | Texas Tech 20, New Mexico 0 | Box score |
| Oct 24, 1942 | Tulane 29, 19North Carolina 14upset | Box score |
| Oct 24, 1942 | 14UCLA 14, 9Santa Clara 6upset | Box score |
| Oct 24, 1942 | Utah 21, Denver 12 | Box score |
| Oct 24, 1942 | Virginia Tech 19, Washington and Lee 6 | Box score |
| Oct 24, 1942 | Washington State 26, Oregon State 13 | Box score |
| Oct 24, 1942 | West Texas 7, UTEP 0 | Box score |
| Oct 24, 1942 | William & Mary 61, George Washington 0 | Box score |
| Oct 24, 1942 | 7Wisconsin 13, Purdue 0 | Box score |
| Oct 25, 1942 | 10Boston College 27, Wake Forest 0 | Box score |