| Sep 25, 1942 | Alabama 54, Louisiana 0 | Box score |
| Sep 25, 1942 | The Citadel 32, Camp Davis 0 | Box score |
| Sep 25, 1942 | Creighton 20, Colorado Springs Field 0 | Box score |
| Sep 25, 1942 | Kentucky 35, Xavier 19 | Box score |
| Sep 25, 1942 | Syracuse 58, Clarkson 6 | Box score |
| Sep 26, 1942 | Arkansas 27, Wichita State 0 | Box score |
| Sep 26, 1942 | BYU 12, Montana 6 | Box score |
| Sep 26, 1942 | Clemson 0, VMI 0 | Box score |
| Sep 26, 1942 | Colgate 49, St. Lawrence 0 | Box score |
| Sep 26, 1942 | Colorado 54, Colorado School of Mines 0 | Box score |
| Sep 26, 1942 | Columbia 39, Fort Monmouth 0 | Box score |
| Sep 26, 1942 | Cornell 20, Lafayette 16 | Box score |
| Sep 26, 1942 | Duquesne 26, Waynesburg 0 | Box score |
| Sep 26, 1942 | Florida 45, Randolph Macon 0 | Box score |
| Sep 26, 1942 | Fordham 14, Purdue 7 | Box score |
| Sep 26, 1942 | George Washington 20, McDaniel 0 | Box score |
| Sep 26, 1942 | Georgetown 7, Temple 0upset | Box score |
| Sep 26, 1942 | Illinois 46, South Dakota 0 | Box score |
| Sep 26, 1942 | Indiana 53, Butler 0 | Box score |
| Sep 26, 1942 | Maryland 34, UConn 0 | Box score |
| Sep 26, 1942 | Ole Miss 39, Western Kentucky 6 | Box score |
| Sep 26, 1942 | Mississippi State 35, Union (Tennessee) 2 | Box score |
| Sep 26, 1942 | New Mexico 26, Northern Arizona 6 | Box score |
| Sep 26, 1942 | NC State 13, Richmond 0 | Box score |
| Sep 26, 1942 | Ohio State 59, Fort Knox 0 | Box score |
| Sep 26, 1942 | Oregon State 32, Idaho 0 | Box score |
| Sep 26, 1942 | Princeton 20, Lakehurst NAS 6 | Box score |
| Sep 26, 1942 | Rice 18, Corpus Christi NAS 7 | Box score |
| Sep 26, 1942 | SMU 26, North Texas 7 | Box score |
| Sep 26, 1942 | St. Ambrose 12, Drake 6upset | Box score |
| Sep 26, 1942 | Utah State 47, Idaho Marines 0 | Box score |
| Sep 26, 1942 | Vanderbilt 52, Tennessee Tech 0 | Box score |
| Sep 26, 1942 | Virginia 12, Hampden Sydney 0 | Box score |
| Sep 26, 1942 | Virginia Tech 7, Furman 6 | Box score |
| Sep 26, 1942 | Washington 27, Pacific 0 | Box score |
| Sep 26, 1942 | Washington St. Louis 26, Southeast Missouri State 7 | Box score |
| Sep 27, 1942 | Tulsa 84, Waco Field 0 | Box score |