1888: Week 9
Five games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 21, 1888 | Pennsylvania 50, Lafayette 0upset | Box score |
| Nov 24, 1888 | Yale 10, Princeton 0 | Box score |
Everyone else
| Nov 24, 1888 | Amherst 45, Massachusetts 4 | Box score |
| Nov 24, 1888 | Wesleyan (CT) 24, WPI 4 | Box score |
| Nov 24, 1888 | Williams 22, MIT 0 | Box score |