1888: Week 10
Seven games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Dec 1, 1888 | Pennsylvania 20, Navy 9 | Box score |
Everyone else
| Nov 27, 1888 | Lehigh 16, Lafayette 0 | Box score |
| Nov 27, 1888 | Pennsylvania 18, Wesleyan (CT) 6 | Box score |
| Nov 29, 1888 | Dartmouth 40, Amherst 0 | Box score |
| Nov 29, 1888 | WPI 6, Trinity (CT) 0 | Box score |
| Nov 30, 1888 | Pennsylvania 24, Johns Hopkins 10 | Box score |
| Dec 1, 1888 | Lehigh 4, Cornell 0 | Box score |