1881: Week 5
Eight games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 2, 1881 | Harvard 2, Pennsylvania 0 | Box score |
| Nov 2, 1881 | Yale 2, Michigan 0 | Box score |
| Nov 4, 1881 | Princeton 1, Michigan 0 | Box score |
| Nov 5, 1881 | Harvard 1, Columbia 0 | Box score |
| Nov 5, 1881 | Princeton 4, Pennsylvania 0 | Box score |
Everyone else
| Nov 3, 1881 | Stevens 1, Rutgers 0upset | Box score |
| Nov 5, 1881 | Stevens 2, City College of New York 2 | Box score |
| Nov 5, 1881 | Yale 4, Amherst 0 | Box score |