1880: Week 6
Five games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 10, 1880 | Yale 13, Columbia 0 | Box score |
| Nov 13, 1880 | Columbia 3, Rutgers 0 | Box score |
| Nov 13, 1880 | Princeton 2, Harvard 1 | Box score |
| Nov 13, 1880 | Yale 8, Brown 0 | Box score |
Everyone else
| Nov 13, 1880 | Pennsylvania 5, Stevens 0 | Box score |