1880: Week 5
Four games. Winners are listed first; numbers before names are AP ranks going in.
FBS vs. FBS
| Nov 2, 1880 | Princeton 8, Rutgers 0 | Box score |
| Nov 6, 1880 | Harvard 3, Columbia 0 | Box score |
Everyone else
| Nov 2, 1880 | Stevens 2, City College of New York 0 | Box score |
| Nov 6, 1880 | Pennsylvania 3, Stevens 0 | Box score |