| Oct 21, 1995 | 21Alabama 23, Ole Miss 9 | Box score |
| Oct 21, 1995 | Army 49, Boston College 7upset | Box score |
| Oct 21, 1995 | 13Auburn 34, Western Michigan 13 | Box score |
| Oct 21, 1995 | BYU 23, Wyoming 20 | Box score |
| Oct 21, 1995 | California 13, Oregon State 12 | Box score |
| Oct 21, 1995 | Central Michigan 27, Kent State 16 | Box score |
| Oct 21, 1995 | Cincinnati 28, Memphis 3 | Box score |
| Oct 21, 1995 | Clemson 17, Maryland 0 | Box score |
| Oct 21, 1995 | 9Colorado 50, Iowa State 28 | Box score |
| Oct 21, 1995 | East Carolina 32, Temple 22 | Box score |
| Oct 21, 1995 | Eastern Michigan 40, Ball State 35 | Box score |
| Oct 21, 1995 | 1Florida State 42, Georgia Tech 10 | Box score |
| Oct 21, 1995 | Georgia 12, Kentucky 3 | Box score |
| Oct 21, 1995 | Houston 38, SMU 15 | Box score |
| Oct 21, 1995 | 7Kansas 38, 15Oklahoma 17 | Box score |
| Oct 21, 1995 | Louisiana 45, Pacific 3 | Box score |
| Oct 21, 1995 | LSU 49, North Texas 7 | Box score |
| Oct 21, 1995 | Miami 17, Pittsburgh 16 | Box score |
| Oct 21, 1995 | 10Michigan 34, Indiana 17 | Box score |
| Oct 21, 1995 | Michigan State 34, Minnesota 31 | Box score |
| Oct 21, 1995 | 2Nebraska 49, 8Kansas State 25 | Box score |
| Oct 21, 1995 | Nevada 49, Louisiana Tech 45 | Box score |
| Oct 21, 1995 | New Mexico 22, Colorado State 14upset | Box score |
| Oct 21, 1995 | North Carolina 31, Wake Forest 7 | Box score |
| Oct 21, 1995 | NC State 41, Duke 38 | Box score |
| Oct 21, 1995 | 11Northwestern 35, 24Wisconsin 0 | Box score |
| Oct 21, 1995 | 17Notre Dame 38, 5USC 10upset | Box score |
| Oct 21, 1995 | Ohio 29, Akron 23 | Box score |
| Oct 21, 1995 | 4Ohio State 28, Purdue 0 | Box score |
| Oct 21, 1995 | Oklahoma State 30, Missouri 26 | Box score |
| Oct 21, 1995 | 12Oregon 26, Washington State 7 | Box score |
| Oct 21, 1995 | 19Penn State 41, 18Iowa 27upset | Box score |
| Oct 21, 1995 | San Diego State 49, San José State 20 | Box score |
| Oct 21, 1995 | South Carolina 52, Vanderbilt 14 | Box score |
| Oct 21, 1995 | Syracuse 22, West Virginia 0 | Box score |
| Oct 21, 1995 | 16Texas 17, 14Virginia 16upset | Box score |
| Oct 21, 1995 | 22Texas A&M 24, Baylor 9 | Box score |
| Oct 21, 1995 | TCU 16, Tulane 11 | Box score |
| Oct 21, 1995 | 25Texas Tech 31, Rice 26 | Box score |
| Oct 21, 1995 | Toledo 35, Bowling Green 16 | Box score |
| Oct 21, 1995 | UCLA 42, 23Stanford 28upset | Box score |
| Oct 21, 1995 | Utah 22, Air Force 21 | Box score |
| Oct 21, 1995 | Utah State 27, New Mexico State 14 | Box score |
| Oct 21, 1995 | Virginia Tech 45, Rutgers 17 | Box score |
| Oct 21, 1995 | 20Washington 31, Arizona 17 | Box score |