| Oct 16, 1993 | 11Arizona 27, Stanford 24 | Box score |
| Oct 16, 1993 | 19Auburn 38, 4Florida 35upset | Box score |
| Oct 16, 1993 | Bowling Green 49, Akron 7 | Box score |
| Oct 16, 1993 | Cincinnati 44, Ball State 12 | Box score |
| Oct 16, 1993 | 20Colorado 27, 9Oklahoma 10upset | Box score |
| Oct 16, 1993 | East Carolina 31, Louisiana Tech 28 | Box score |
| Oct 16, 1993 | Eastern Michigan 28, Central Michigan 21upset | Box score |
| Oct 16, 1993 | 1Florida State 40, 15Virginia 14 | Box score |
| Oct 16, 1993 | Fresno State 33, Air Force 20 | Box score |
| Oct 16, 1993 | Georgia 41, Vanderbilt 3 | Box score |
| Oct 16, 1993 | Illinois 49, Iowa 3 | Box score |
| Oct 16, 1993 | Kansas 35, Iowa State 20 | Box score |
| Oct 16, 1993 | Kentucky 35, LSU 17 | Box score |
| Oct 16, 1993 | Louisiana 19, Arkansas State 3 | Box score |
| Oct 16, 1993 | 23Louisville 35, Southern Miss 27 | Box score |
| Oct 16, 1993 | Maryland 26, Duke 18 | Box score |
| Oct 16, 1993 | Miami (OH) 22, Toledo 19upset | Box score |
| Oct 16, 1993 | 18Michigan 21, 7Penn State 13upset | Box score |
| Oct 16, 1993 | Minnesota 28, Northwestern 26 | Box score |
| Oct 16, 1993 | Ole Miss 19, Arkansas 0 | Box score |
| Oct 16, 1993 | Mississippi State 23, South Carolina 0 | Box score |
| Oct 16, 1993 | Missouri 42, Oklahoma State 9 | Box score |
| Oct 16, 1993 | 6Nebraska 45, Kansas State 28 | Box score |
| Oct 16, 1993 | Nevada 48, Utah State 44 | Box score |
| Oct 16, 1993 | 14North Carolina 41, Georgia Tech 3 | Box score |
| Oct 16, 1993 | Northern Illinois 21, Pacific 16 | Box score |
| Oct 16, 1993 | 3Notre Dame 45, BYU 20 | Box score |
| Oct 16, 1993 | Ohio 15, Kent State 10 | Box score |
| Oct 16, 1993 | 5Ohio State 28, 25Michigan State 21 | Box score |
| Oct 16, 1993 | Oregon 45, Arizona State 36 | Box score |
| Oct 16, 1993 | Rutgers 45, Army 38 | Box score |
| Oct 16, 1993 | San Diego State 30, Colorado State 3 | Box score |
| Oct 16, 1993 | San José State 52, New Mexico State 13 | Box score |
| Oct 16, 1993 | USC 34, Oregon State 9 | Box score |
| Oct 16, 1993 | Houston 28, SMU 28 | Box score |
| Oct 16, 1993 | 24Syracuse 24, Pittsburgh 21 | Box score |
| Oct 16, 1993 | 2Alabama 17, 10Tennessee 17 | Box score |
| Oct 16, 1993 | 13Texas A&M 34, Baylor 17 | Box score |
| Oct 16, 1993 | TCU 14, Tulane 7 | Box score |
| Oct 16, 1993 | Texas Tech 45, Rice 16 | Box score |
| Oct 16, 1993 | Tulsa 23, Memphis 19upset | Box score |
| Oct 16, 1993 | 22UCLA 39, 12Washington 25upset | Box score |
| Oct 16, 1993 | Utah 45, UTEP 29 | Box score |
| Oct 16, 1993 | Virginia Tech 55, Temple 7 | Box score |
| Oct 16, 1993 | Wake Forest 20, Clemson 16upset | Box score |
| Oct 16, 1993 | Washington State 34, 21California 7upset | Box score |
| Oct 16, 1993 | 16Wisconsin 42, Purdue 28 | Box score |