| Nov 16, 1991 | 7Alabama 10, Memphis 7 | Box score |
| Nov 16, 1991 | Arizona 31, USC 14 | Box score |
| Nov 16, 1991 | Army 19, Akron 0 | Box score |
| Nov 16, 1991 | Bowling Green 14, Ball State 13 | Box score |
| Nov 16, 1991 | San Diego State 52, 23BYU 52 | Box score |
| Nov 16, 1991 | 6California 25, Arizona State 6 | Box score |
| Nov 16, 1991 | Central Michigan 27, Western Michigan 17 | Box score |
| Nov 16, 1991 | 15Clemson 40, Maryland 7 | Box score |
| Nov 16, 1991 | 16Colorado 30, Kansas 24 | Box score |
| Nov 16, 1991 | 14East Carolina 24, Virginia Tech 17 | Box score |
| Nov 16, 1991 | 5Florida 35, Kentucky 26 | Box score |
| Nov 16, 1991 | Fresno State 38, Cal State Fullerton 7 | Box score |
| Nov 16, 1991 | Georgia 37, Auburn 27 | Box score |
| Nov 16, 1991 | Georgia Tech 27, Wake Forest 3 | Box score |
| Nov 16, 1991 | San José State 35, Hawai’i 35 | Box score |
| Nov 16, 1991 | Houston 41, Rice 21 | Box score |
| Nov 16, 1991 | 9Iowa 24, Northwestern 10 | Box score |
| Nov 16, 1991 | Kansas State 32, Missouri 0 | Box score |
| Nov 16, 1991 | Louisiana 17, Arkansas State 13 | Box score |
| Nov 16, 1991 | Louisiana Tech 30, Southern Miss 14 | Box score |
| Nov 16, 1991 | 2Miami 17, 1Florida State 16upset | Box score |
| Nov 16, 1991 | Miami (OH) 20, Kent State 9 | Box score |
| Nov 16, 1991 | 4Michigan 20, 25Illinois 0 | Box score |
| Nov 16, 1991 | Mississippi State 28, LSU 19 | Box score |
| Nov 16, 1991 | 11Nebraska 38, Iowa State 13 | Box score |
| Nov 16, 1991 | UNLV 38, New Mexico State 28 | Box score |
| Nov 16, 1991 | New Mexico 38, Colorado State 36upset | Box score |
| Nov 16, 1991 | North Carolina 21, South Carolina 17 | Box score |
| Nov 16, 1991 | 24NC State 32, Duke 31 | Box score |
| Nov 16, 1991 | 19Ohio State 20, Indiana 16 | Box score |
| Nov 16, 1991 | 18Oklahoma 21, Oklahoma State 6 | Box score |
| Nov 16, 1991 | 8Penn State 35, 12Notre Dame 13 | Box score |
| Nov 16, 1991 | Purdue 27, Michigan State 17 | Box score |
| Nov 16, 1991 | Rutgers 41, Temple 0 | Box score |
| Nov 16, 1991 | 22Stanford 49, Washington State 14 | Box score |
| Nov 16, 1991 | 17Syracuse 38, Boston College 16 | Box score |
| Nov 16, 1991 | 10Tennessee 36, Ole Miss 25 | Box score |
| Nov 16, 1991 | Texas 32, TCU 0 | Box score |
| Nov 16, 1991 | 13Texas A&M 13, Arkansas 3 | Box score |
| Nov 16, 1991 | Texas Tech 31, 20Baylor 24upset | Box score |
| Nov 16, 1991 | Toledo 21, Eastern Michigan 14 | Box score |
| Nov 16, 1991 | Tulsa 40, Louisville 0 | Box score |
| Nov 16, 1991 | UCLA 16, Oregon 7 | Box score |
| Nov 16, 1991 | Utah 10, UTEP 9 | Box score |
| Nov 16, 1991 | Utah State 21, Pacific 14 | Box score |
| Nov 16, 1991 | 3Washington 58, Oregon State 6 | Box score |
| Nov 16, 1991 | Wisconsin 19, Minnesota 16upset | Box score |