| Nov 12, 1988 | 18Alabama 17, Louisiana 0 | Box score |
| Nov 12, 1988 | Arizona 41, Oregon 27 | Box score |
| Nov 12, 1988 | 11Arkansas 25, Texas A&M 20 | Box score |
| Nov 12, 1988 | Army 24, Vanderbilt 19 | Box score |
| Nov 12, 1988 | 9Auburn 20, 17Georgia 10 | Box score |
| Nov 12, 1988 | Baylor 20, Rice 10 | Box score |
| Nov 12, 1988 | BYU 49, Air Force 31 | Box score |
| Nov 12, 1988 | Cal State Fullerton 58, San José State 13 | Box score |
| Nov 12, 1988 | 16Clemson 49, Maryland 25 | Box score |
| Nov 12, 1988 | NC State 43, Duke 43 | Box score |
| Nov 12, 1988 | Eastern Michigan 28, Bowling Green 3 | Box score |
| Nov 12, 1988 | Florida 24, Kentucky 19 | Box score |
| Nov 12, 1988 | 5Florida State 41, Virginia Tech 14 | Box score |
| Nov 12, 1988 | Fresno State 31, UNLV 14 | Box score |
| Nov 12, 1988 | Houston 34, 10Wyoming 10upset | Box score |
| Nov 12, 1988 | Iowa State 16, Kansas State 7 | Box score |
| Nov 12, 1988 | Kent State 17, Miami (OH) 11 | Box score |
| Nov 12, 1988 | Long Beach State 21, New Mexico State 16 | Box score |
| Nov 12, 1988 | 12LSU 20, Mississippi State 3 | Box score |
| Nov 12, 1988 | Memphis 26, Tulsa 20 | Box score |
| Nov 12, 1988 | 13Michigan 38, Illinois 9 | Box score |
| Nov 12, 1988 | Michigan State 38, Indiana 12 | Box score |
| Nov 12, 1988 | 7Nebraska 7, 19Colorado 0 | Box score |
| Nov 12, 1988 | New Mexico 24, Colorado State 23 | Box score |
| Nov 12, 1988 | Northern Illinois 15, Western Michigan 7 | Box score |
| Nov 12, 1988 | Northwestern 28, Purdue 7 | Box score |
| Nov 12, 1988 | Ohio 27, Ball State 25upset | Box score |
| Nov 12, 1988 | Iowa 24, Ohio State 24 | Box score |
| Nov 12, 1988 | 8Oklahoma 16, Missouri 7 | Box score |
| Nov 12, 1988 | 14Oklahoma State 63, Kansas 24 | Box score |
| Nov 12, 1988 | Pittsburgh 14, Penn State 7 | Box score |
| Nov 12, 1988 | South Carolina 19, Navy 8 | Box score |
| Nov 12, 1988 | 2USC 50, Arizona State 0 | Box score |
| Nov 12, 1988 | 15Syracuse 45, Boston College 20 | Box score |
| Nov 12, 1988 | Temple 37, Akron 17 | Box score |
| Nov 12, 1988 | Tennessee 20, Ole Miss 12 | Box score |
| Nov 12, 1988 | Texas 30, TCU 21 | Box score |
| Nov 12, 1988 | UTEP 58, San Diego State 7 | Box score |
| Nov 12, 1988 | Toledo 20, Central Michigan 13 | Box score |
| Nov 12, 1988 | 6UCLA 27, Stanford 17 | Box score |
| Nov 12, 1988 | Utah 42, Utah State 21 | Box score |
| Nov 12, 1988 | Virginia 27, North Carolina 24 | Box score |
| Nov 12, 1988 | Wake Forest 28, Georgia Tech 24 | Box score |
| Nov 12, 1988 | Washington 28, California 27 | Box score |
| Nov 12, 1988 | 20Washington State 36, Oregon State 27 | Box score |
| Nov 12, 1988 | 4West Virginia 35, Rutgers 25 | Box score |
| Nov 12, 1988 | Wisconsin 14, Minnesota 7 | Box score |