| Oct 18, 1986 | 2Alabama 56, Tennessee 28 | Box score |
| Oct 18, 1986 | 16Arizona 23, Oregon State 12 | Box score |
| Oct 18, 1986 | 10Arizona State 29, 15USC 20 | Box score |
| Oct 18, 1986 | 14Arkansas 21, Texas 14 | Box score |
| Oct 18, 1986 | 7Auburn 31, Georgia Tech 10 | Box score |
| Oct 18, 1986 | Ball State 26, Kent State 17 | Box score |
| Oct 18, 1986 | Boston College 41, Louisville 7 | Box score |
| Oct 18, 1986 | BYU 34, Wyoming 22 | Box score |
| Oct 18, 1986 | Cal State Fullerton 33, Utah State 0 | Box score |
| Oct 18, 1986 | 17Clemson 35, Duke 3 | Box score |
| Oct 18, 1986 | Colorado 31, Iowa State 3 | Box score |
| Oct 18, 1986 | Colorado State 31, Hawai’i 7 | Box score |
| Oct 18, 1986 | Eastern Michigan 33, Ohio 31 | Box score |
| Oct 18, 1986 | Florida 15, Rutgers 3 | Box score |
| Oct 18, 1986 | Florida State 59, Wichita State 3 | Box score |
| Oct 18, 1986 | Fresno State 10, Pacific 9 | Box score |
| Oct 18, 1986 | Georgia 38, Vanderbilt 16 | Box score |
| Oct 18, 1986 | Kansas State 29, Kansas 12upset | Box score |
| Oct 18, 1986 | Long Beach State 38, New Mexico State 7 | Box score |
| Oct 18, 1986 | 12LSU 25, Kentucky 16 | Box score |
| Oct 18, 1986 | 1Miami 45, Cincinnati 13 | Box score |
| Oct 18, 1986 | 4Michigan 20, 8Iowa 17 | Box score |
| Oct 18, 1986 | Michigan State 29, Illinois 21 | Box score |
| Oct 18, 1986 | Minnesota 19, Indiana 17 | Box score |
| Oct 18, 1986 | Ole Miss 21, Louisiana 20 | Box score |
| Oct 18, 1986 | 13Mississippi State 34, Tulane 27 | Box score |
| Oct 18, 1986 | 3Nebraska 48, Missouri 17 | Box score |
| Oct 18, 1986 | New Mexico 47, Utah 43 | Box score |
| Oct 18, 1986 | NC State 35, 18North Carolina 34upset | Box score |
| Oct 18, 1986 | Notre Dame 31, Air Force 3 | Box score |
| Oct 18, 1986 | Ohio State 39, Purdue 11 | Box score |
| Oct 18, 1986 | 5Oklahoma 19, Oklahoma State 0 | Box score |
| Oct 18, 1986 | 6Penn State 42, Syracuse 3 | Box score |
| Oct 18, 1986 | San Diego State 15, UTEP 10 | Box score |
| Oct 18, 1986 | San José State 23, UNLV 20 | Box score |
| Oct 18, 1986 | 20SMU 10, Houston 3 | Box score |
| Oct 18, 1986 | Southern Miss 14, Memphis 9 | Box score |
| Oct 18, 1986 | Stanford 41, Oregon 7 | Box score |
| Oct 18, 1986 | Temple 29, Virginia Tech 13 | Box score |
| Oct 18, 1986 | 11Texas A&M 31, 20Baylor 30 | Box score |
| Oct 18, 1986 | Texas Tech 49, Rice 21 | Box score |
| Oct 18, 1986 | Toledo 29, Northern Illinois 28 | Box score |
| Oct 18, 1986 | Tulsa 42, Central Michigan 6 | Box score |
| Oct 18, 1986 | 19UCLA 36, California 10 | Box score |
| Oct 18, 1986 | Wake Forest 27, Maryland 21upset | Box score |
| Oct 18, 1986 | 9Washington 48, Bowling Green 0 | Box score |
| Oct 18, 1986 | Western Michigan 27, Miami (OH) 17upset | Box score |
| Oct 18, 1986 | Wisconsin 35, Northwestern 27 | Box score |