| Sep 21, 1985 | Air Force 59, Rice 17 | Box score |
| Sep 21, 1985 | 16Alabama 45, Cincinnati 10 | Box score |
| Sep 21, 1985 | Arizona 23, California 17 | Box score |
| Sep 21, 1985 | Arizona State 27, Pacific 0 | Box score |
| Sep 21, 1985 | 14Arkansas 24, Tulsa 0 | Box score |
| Sep 21, 1985 | Army 20, Rutgers 16 | Box score |
| Sep 21, 1985 | Baylor 20, 3USC 13upset | Box score |
| Sep 21, 1985 | Boston College 29, Pittsburgh 22 | Box score |
| Sep 21, 1985 | Bowling Green 28, Miami (OH) 24 | Box score |
| Sep 21, 1985 | 13BYU 26, Temple 24 | Box score |
| Sep 21, 1985 | Duke 34, Ohio 13 | Box score |
| Sep 21, 1985 | 6Florida State 19, Memphis 10 | Box score |
| Sep 21, 1985 | Fresno State 33, Oregon State 24 | Box score |
| Sep 21, 1985 | Georgia 20, Clemson 13 | Box score |
| Sep 21, 1985 | Indiana 38, Navy 35 | Box score |
| Sep 21, 1985 | 4Iowa 48, Northern Illinois 20 | Box score |
| Sep 21, 1985 | Iowa State 20, Vanderbilt 17 | Box score |
| Sep 21, 1985 | Kentucky 16, Tulane 11 | Box score |
| Sep 21, 1985 | Long Beach State 33, Hawai’i 30upset | Box score |
| Sep 21, 1985 | 9LSU 17, Colorado State 3 | Box score |
| Sep 21, 1985 | 17Maryland 28, West Virginia 0 | Box score |
| Sep 21, 1985 | 19Michigan 34, 15South Carolina 3upset | Box score |
| Sep 21, 1985 | Mississippi State 23, Southern Miss 20 | Box score |
| Sep 21, 1985 | 18Nebraska 52, 20Illinois 25 | Box score |
| Sep 21, 1985 | New Mexico State 22, UTEP 20 | Box score |
| Sep 21, 1985 | NC State 20, Wake Forest 17upset | Box score |
| Sep 21, 1985 | Notre Dame 27, Michigan State 10 | Box score |
| Sep 21, 1985 | 7Ohio State 36, Colorado 13 | Box score |
| Sep 21, 1985 | Oregon 45, Stanford 28 | Box score |
| Sep 21, 1985 | 10Penn State 17, East Carolina 10 | Box score |
| Sep 21, 1985 | Purdue 37, Ball State 18 | Box score |
| Sep 21, 1985 | Syracuse 34, Kent State 0 | Box score |
| Sep 21, 1985 | Texas 21, Missouri 17 | Box score |
| Sep 21, 1985 | TCU 24, Kansas State 22 | Box score |
| Sep 21, 1985 | Toledo 22, Wichita State 15 | Box score |
| Sep 21, 1985 | 12UCLA 34, San Diego State 16 | Box score |
| Sep 21, 1985 | Utah 44, Washington State 37 | Box score |
| Sep 21, 1985 | Utah State 35, San José State 32 | Box score |
| Sep 21, 1985 | Virginia 24, Georgia Tech 13 | Box score |
| Sep 21, 1985 | Washington 29, Houston 12 | Box score |
| Sep 21, 1985 | Wisconsin 26, UNLV 23 | Box score |
| Sep 21, 1985 | Wyoming 31, Cal State Fullerton 8 | Box score |