| Nov 23, 1985 | 13Air Force 27, Hawai’i 20 | Box score |
| Nov 23, 1985 | Arizona 16, Arizona State 13 | Box score |
| Nov 23, 1985 | 18Arkansas 15, SMU 9 | Box score |
| Nov 23, 1985 | Bowling Green 38, Ohio 17 | Box score |
| Nov 23, 1985 | 11BYU 38, Utah 28 | Box score |
| Nov 23, 1985 | Cal State Fullerton 38, Long Beach State 27 | Box score |
| Nov 23, 1985 | Central Michigan 30, Northern Illinois 21 | Box score |
| Nov 23, 1985 | Clemson 24, South Carolina 17 | Box score |
| Nov 23, 1985 | Colorado 30, Kansas State 0 | Box score |
| Nov 23, 1985 | Duke 23, North Carolina 21upset | Box score |
| Nov 23, 1985 | Fresno State 47, Wichita State 6 | Box score |
| Nov 23, 1985 | Houston 17, Texas Tech 16 | Box score |
| Nov 23, 1985 | Illinois 45, Northwestern 20 | Box score |
| Nov 23, 1985 | 3Iowa 31, Minnesota 9 | Box score |
| Nov 23, 1985 | Iowa State 15, 7Oklahoma State 10upset | Box score |
| Nov 23, 1985 | Kansas 34, Missouri 20 | Box score |
| Nov 23, 1985 | 17LSU 10, Notre Dame 7 | Box score |
| Nov 23, 1985 | 4Miami 24, Colorado State 3 | Box score |
| Nov 23, 1985 | Miami (OH) 16, Cincinnati 10 | Box score |
| Nov 23, 1985 | 6Michigan 27, 12Ohio State 17 | Box score |
| Nov 23, 1985 | Michigan State 41, Wisconsin 7 | Box score |
| Nov 23, 1985 | Ole Miss 45, Mississippi State 27 | Box score |
| Nov 23, 1985 | 5Oklahoma 27, 2Nebraska 7upset | Box score |
| Nov 23, 1985 | Oregon 34, Oregon State 13 | Box score |
| Nov 23, 1985 | 1Penn State 31, Pittsburgh 0 | Box score |
| Nov 23, 1985 | Purdue 34, Indiana 21 | Box score |
| Nov 23, 1985 | San Diego State 55, New Mexico 20 | Box score |
| Nov 23, 1985 | USC 17, 8UCLA 13upset | Box score |
| Nov 23, 1985 | Southern Miss 24, Tulane 6 | Box score |
| Nov 23, 1985 | Stanford 24, California 22 | Box score |
| Nov 23, 1985 | Syracuse 31, Rutgers 14 | Box score |
| Nov 23, 1985 | 16Tennessee 42, Kentucky 0 | Box score |
| Nov 23, 1985 | Texas 17, 15Baylor 10upset | Box score |
| Nov 23, 1985 | 19Texas A&M 53, TCU 6 | Box score |
| Nov 23, 1985 | Toledo 10, Kent State 7 | Box score |
| Nov 23, 1985 | Utah State 40, New Mexico State 23 | Box score |
| Nov 23, 1985 | Washington State 21, Washington 20upset | Box score |
| Nov 23, 1985 | Western Michigan 38, Eastern Michigan 21 | Box score |