| Oct 27, 1979 | 1Alabama 31, Virginia Tech 7 | Box score |
| Oct 27, 1979 | Arizona State 28, Utah State 14 | Box score |
| Oct 27, 1979 | Ball State 38, Bowling Green 23 | Box score |
| Oct 27, 1979 | Baylor 16, TCU 3 | Box score |
| Oct 27, 1979 | Boston College 29, Army 16upset | Box score |
| Oct 27, 1979 | 11BYU 59, New Mexico 7 | Box score |
| Oct 27, 1979 | Central Michigan 44, Kent State 21 | Box score |
| Oct 27, 1979 | Cincinnati 17, Richmond 14 | Box score |
| Oct 27, 1979 | Colgate 24, Columbia 14 | Box score |
| Oct 27, 1979 | Colorado State 20, Air Force 6 | Box score |
| Oct 27, 1979 | Cornell 21, Dartmouth 10 | Box score |
| Oct 27, 1979 | 15North Carolina 24, East Carolina 24 | Box score |
| Oct 27, 1979 | 8Florida State 24, LSU 19 | Box score |
| Oct 27, 1979 | Fresno State 33, Pacific 10upset | Box score |
| Oct 27, 1979 | Georgia 20, Kentucky 6 | Box score |
| Oct 27, 1979 | Hawai’i 27, UTEP 12 | Box score |
| Oct 27, 1979 | Holy Cross 14, Brown 7upset | Box score |
| Oct 27, 1979 | 6Houston 13, 4Arkansas 10upset | Box score |
| Oct 27, 1979 | Minnesota 17, Illinois 17 | Box score |
| Oct 27, 1979 | Indiana State 23, Illinois State 21 | Box score |
| Oct 27, 1979 | Iowa 24, Wisconsin 13 | Box score |
| Oct 27, 1979 | Kansas State 19, Missouri 3upset | Box score |
| Oct 27, 1979 | Lamar 20, Arkansas State 10upset | Box score |
| Oct 27, 1979 | Maryland 27, Duke 0 | Box score |
| Oct 27, 1979 | McNeese 24, Chattanooga 17 | Box score |
| Oct 27, 1979 | Memphis 22, North Texas 0 | Box score |
| Oct 27, 1979 | 10Michigan 27, Indiana 21 | Box score |
| Oct 27, 1979 | Ole Miss 63, Vanderbilt 28 | Box score |
| Oct 27, 1979 | 2Nebraska 38, Colorado 10 | Box score |
| Oct 27, 1979 | UNLV 28, Wyoming 24 | Box score |
| Oct 27, 1979 | NC State 16, Clemson 13upset | Box score |
| Oct 27, 1979 | 14Notre Dame 18, South Carolina 17 | Box score |
| Oct 27, 1979 | 4Ohio State 42, Michigan State 0 | Box score |
| Oct 27, 1979 | 7Oklahoma 38, Iowa State 9 | Box score |
| Oct 27, 1979 | Oklahoma State 30, Kansas 17 | Box score |
| Oct 27, 1979 | Oregon 37, Washington State 26 | Box score |
| Oct 27, 1979 | Oregon State 33, Stanford 31upset | Box score |
| Oct 27, 1979 | Penn State 31, West Virginia 6 | Box score |
| Oct 27, 1979 | 12Pittsburgh 24, 17Navy 7 | Box score |
| Oct 27, 1979 | Princeton 9, Harvard 7 | Box score |
| Oct 27, 1979 | 16Purdue 20, Northwestern 16 | Box score |
| Oct 27, 1979 | San Diego State 17, Utah 13 | Box score |
| Oct 27, 1979 | San José State 53, Long Beach State 42 | Box score |
| Oct 27, 1979 | 3USC 24, California 14 | Box score |
| Oct 27, 1979 | Southern Illinois 21, Northern Illinois 11 | Box score |
| Oct 27, 1979 | Southern Miss 21, Mississippi State 7 | Box score |
| Oct 27, 1979 | Syracuse 25, Miami 15 | Box score |
| Oct 27, 1979 | 9Texas 30, SMU 6 | Box score |
| Oct 27, 1979 | Texas A&M 41, Rice 15 | Box score |
| Oct 27, 1979 | Texas–Arlington 30, Louisiana Tech 16 | Box score |
| Oct 27, 1979 | Toledo 24, Miami (OH) 21upset | Box score |
| Oct 27, 1979 | Tulane 12, Georgia Tech 7 | Box score |
| Oct 27, 1979 | Tulsa 20, Florida 10 | Box score |
| Oct 27, 1979 | Villanova 24, Marshall 14 | Box score |
| Oct 27, 1979 | VMI 21, Furman 20 | Box score |
| Oct 27, 1979 | 18Wake Forest 42, 13Auburn 38upset | Box score |
| Oct 27, 1979 | 20Washington 34, UCLA 14 | Box score |
| Oct 27, 1979 | West Texas 58, Wichita State 0 | Box score |
| Oct 27, 1979 | Western Michigan 20, Ohio 6 | Box score |
| Oct 27, 1979 | Yale 24, Pennsylvania 6 | Box score |