| Nov 11, 1977 | Michigan State 44, Northwestern 3 | Box score |
| Nov 12, 1977 | Air Force 34, Vanderbilt 28 | Box score |
| Nov 12, 1977 | 2Alabama 36, Miami 0 | Box score |
| Nov 12, 1977 | Arizona 15, New Mexico 13 | Box score |
| Nov 12, 1977 | 17Arizona State 24, 13BYU 13upset | Box score |
| Nov 12, 1977 | 8Arkansas 26, 11Texas A&M 20 | Box score |
| Nov 12, 1977 | Auburn 33, Georgia 14upset | Box score |
| Nov 12, 1977 | Ball State 29, Western Michigan 25 | Box score |
| Nov 12, 1977 | Baylor 24, Rice 14 | Box score |
| Nov 12, 1977 | Bowling Green 39, Ohio 27 | Box score |
| Nov 12, 1977 | Brown 21, Columbia 14 | Box score |
| Nov 12, 1977 | California 48, Oregon 16 | Box score |
| Nov 12, 1977 | Central Michigan 44, Toledo 0 | Box score |
| Nov 12, 1977 | The Citadel 28, App State 20 | Box score |
| Nov 12, 1977 | West Texas 21, Colorado State 21 | Box score |
| Nov 12, 1977 | Eastern Michigan 41, Illinois State 28 | Box score |
| Nov 12, 1977 | 16Florida State 30, Memphis 9 | Box score |
| Nov 12, 1977 | Fresno State 44, Cal State Fullerton 19 | Box score |
| Nov 12, 1977 | Iowa 24, Wisconsin 8upset | Box score |
| Nov 12, 1977 | Iowa State 22, Kansas State 15 | Box score |
| Nov 12, 1977 | 7Kentucky 14, Florida 7 | Box score |
| Nov 12, 1977 | Lamar 35, McNeese 7upset | Box score |
| Nov 12, 1977 | LSU 27, Mississippi State 24 | Box score |
| Nov 12, 1977 | Louisiana Tech 28, Southern Miss 10 | Box score |
| Nov 12, 1977 | Louisville 18, Drake 13 | Box score |
| Nov 12, 1977 | Maryland 27, Richmond 24 | Box score |
| Nov 12, 1977 | Miami (OH) 25, Kent State 0 | Box score |
| Nov 12, 1977 | 6Michigan 40, Purdue 7 | Box score |
| Nov 12, 1977 | Minnesota 21, Illinois 0 | Box score |
| Nov 12, 1977 | Ole Miss 43, Tennessee 14 | Box score |
| Nov 12, 1977 | Missouri 41, Oklahoma State 14 | Box score |
| Nov 12, 1977 | Navy 20, Georgia Tech 16 | Box score |
| Nov 12, 1977 | 12Nebraska 52, Kansas 7 | Box score |
| Nov 12, 1977 | 19North Carolina 35, Virginia 14 | Box score |
| Nov 12, 1977 | NC State 37, Duke 32 | Box score |
| Nov 12, 1977 | 5Notre Dame 21, 15Clemson 17 | Box score |
| Nov 12, 1977 | 4Ohio State 35, Indiana 7 | Box score |
| Nov 12, 1977 | 3Oklahoma 52, Colorado 14 | Box score |
| Nov 12, 1977 | Pacific 31, UL Monroe 0 | Box score |
| Nov 12, 1977 | 9Penn State 44, Temple 7 | Box score |
| Nov 12, 1977 | Pennsylvania 7, Dartmouth 3 | Box score |
| Nov 12, 1977 | 10Pittsburgh 52, Army 26 | Box score |
| Nov 12, 1977 | Princeton 34, Cornell 0 | Box score |
| Nov 12, 1977 | Rutgers 47, Tulane 8 | Box score |
| Nov 12, 1977 | San Diego State 33, Long Beach State 22 | Box score |
| Nov 12, 1977 | South Carolina 24, Wake Forest 14 | Box score |
| Nov 12, 1977 | Stanford 31, San José State 26 | Box score |
| Nov 12, 1977 | Syracuse 20, Boston College 3 | Box score |
| Nov 12, 1977 | Chattanooga 14, Tennessee State 14 | Box score |
| Nov 12, 1977 | 1Texas 44, TCU 14 | Box score |
| Nov 12, 1977 | 18Texas Tech 45, SMU 7 | Box score |
| Nov 12, 1977 | Texas–Arlington 44, Arkansas State 14upset | Box score |
| Nov 12, 1977 | Tulsa 27, New Mexico State 24 | Box score |
| Nov 12, 1977 | UCLA 48, Oregon State 18 | Box score |
| Nov 12, 1977 | Utah 29, UTEP 17 | Box score |
| Nov 12, 1977 | Utah State 32, Wyoming 31 | Box score |
| Nov 12, 1977 | Villanova 24, Holy Cross 0 | Box score |
| Nov 12, 1977 | VMI 31, Furman 28 | Box score |
| Nov 12, 1977 | Washington 28, 14USC 10upset | Box score |
| Nov 12, 1977 | Washington State 45, Idaho 17 | Box score |
| Nov 12, 1977 | West Virginia 20, Virginia Tech 14 | Box score |
| Nov 12, 1977 | Western Carolina 41, Marshall 26 | Box score |
| Nov 12, 1977 | Wichita State 41, Indiana State 14 | Box score |
| Nov 12, 1977 | William & Mary 21, East Carolina 17upset | Box score |
| Nov 12, 1977 | Yale 24, Harvard 7 | Box score |