| Nov 22, 1975 | App State 52, Davidson 7 | Box score |
| Nov 22, 1975 | 11Arizona 38, Utah 14 | Box score |
| Nov 22, 1975 | 19Arkansas 31, Texas Tech 14 | Box score |
| Nov 22, 1975 | Arkansas State 54, Texas–Arlington 7 | Box score |
| Nov 22, 1975 | BYU 20, UTEP 10 | Box score |
| Nov 22, 1975 | Brown 48, Columbia 13 | Box score |
| Nov 22, 1975 | 13California 48, Stanford 15 | Box score |
| Nov 22, 1975 | 9Colorado 33, Kansas State 7 | Box score |
| Nov 22, 1975 | Dartmouth 21, Princeton 16 | Box score |
| Nov 22, 1975 | East Carolina 28, VMI 12 | Box score |
| Nov 22, 1975 | Florida State 33, Houston 22 | Box score |
| Nov 22, 1975 | Harvard 10, Yale 7 | Box score |
| Nov 22, 1975 | Hawai’i 17, Pacific 10 | Box score |
| Nov 22, 1975 | Idaho 25, Northern Illinois 24 | Box score |
| Nov 22, 1975 | Illinois 28, Northwestern 7 | Box score |
| Nov 22, 1975 | Kansas 42, 18Missouri 24upset | Box score |
| Nov 22, 1975 | Lamar 30, Southern Illinois 10 | Box score |
| Nov 22, 1975 | Long Beach State 21, San Diego State 17upset | Box score |
| Nov 22, 1975 | LSU 42, Tulane 6 | Box score |
| Nov 22, 1975 | 20Maryland 62, Virginia 24 | Box score |
| Nov 22, 1975 | McNeese 33, Louisiana 21upset | Box score |
| Nov 22, 1975 | 16Miami (OH) 21, Cincinnati 13 | Box score |
| Nov 22, 1975 | Michigan State 27, Iowa 23 | Box score |
| Nov 22, 1975 | Minnesota 24, Wisconsin 3 | Box score |
| Nov 22, 1975 | Ole Miss 13, Mississippi State 7 | Box score |
| Nov 22, 1975 | New Mexico 52, New Mexico State 28 | Box score |
| Nov 22, 1975 | Duke 17, North Carolina 17 | Box score |
| Nov 22, 1975 | Notre Dame 32, Miami 9 | Box score |
| Nov 22, 1975 | Ohio 38, Marshall 21 | Box score |
| Nov 22, 1975 | 1Ohio State 21, 4Michigan 14 | Box score |
| Nov 22, 1975 | 7Oklahoma 35, 2Nebraska 10upset | Box score |
| Nov 22, 1975 | Oklahoma State 14, Iowa State 7 | Box score |
| Nov 22, 1975 | Oregon 14, Oregon State 7 | Box score |
| Nov 22, 1975 | 10Penn State 7, 17Pittsburgh 6 | Box score |
| Nov 22, 1975 | Pennsylvania 27, Cornell 21 | Box score |
| Nov 22, 1975 | Purdue 9, Indiana 7 | Box score |
| Nov 22, 1975 | Rutgers 56, Colgate 14 | Box score |
| Nov 22, 1975 | South Carolina 56, Clemson 20 | Box score |
| Nov 22, 1975 | SMU 34, Baylor 31 | Box score |
| Nov 22, 1975 | Southern Miss 70, Cal State Fullerton 0 | Box score |
| Nov 22, 1975 | Syracuse 20, West Virginia 19upset | Box score |
| Nov 22, 1975 | Temple 44, Drake 7 | Box score |
| Nov 22, 1975 | Tennessee 17, Kentucky 13 | Box score |
| Nov 22, 1975 | TCU 28, Rice 21upset | Box score |
| Nov 22, 1975 | Toledo 33, Kent State 28 | Box score |
| Nov 22, 1975 | Utah State 28, Colorado State 17 | Box score |
| Nov 22, 1975 | Virginia Tech 40, Wake Forest 10 | Box score |
| Nov 22, 1975 | Washington 28, Washington State 27 | Box score |
| Nov 22, 1975 | West Texas 49, Louisville 23 | Box score |
| Nov 22, 1975 | William & Mary 31, Richmond 21 | Box score |
| Nov 22, 1975 | Wyoming 24, Air Force 10upset | Box score |