| Nov 7, 1975 | Navy 17, Miami 16 | Box score |
| Nov 8, 1975 | Air Force 13, Tulane 12upset | Box score |
| Nov 8, 1975 | 5Alabama 23, LSU 10 | Box score |
| Nov 8, 1975 | App State 39, South Carolina 34upset | Box score |
| Nov 8, 1975 | 15Arizona 31, 13San Diego State 24upset | Box score |
| Nov 8, 1975 | 10Arizona State 21, Wyoming 20 | Box score |
| Nov 8, 1975 | Arkansas 20, Rice 16 | Box score |
| Nov 8, 1975 | Arkansas State 35, Southern Illinois 12 | Box score |
| Nov 8, 1975 | Boston College 31, Army 0 | Box score |
| Nov 8, 1975 | Bowling Green 19, Ohio 17 | Box score |
| Nov 8, 1975 | BYU 24, Utah State 7 | Box score |
| Nov 8, 1975 | Brown 45, Cornell 23 | Box score |
| Nov 8, 1975 | 18California 27, Washington 24 | Box score |
| Nov 8, 1975 | Clemson 38, North Carolina 35 | Box score |
| Nov 8, 1975 | 14Colorado 17, Oklahoma State 7 | Box score |
| Nov 8, 1975 | Colorado State 21, UTEP 17 | Box score |
| Nov 8, 1975 | Dartmouth 22, Columbia 17 | Box score |
| Nov 8, 1975 | Dayton 32, Louisville 13 | Box score |
| Nov 8, 1975 | Duke 42, Wake Forest 14 | Box score |
| Nov 8, 1975 | East Carolina 61, Virginia 10 | Box score |
| Nov 8, 1975 | Georgia 10, 11Florida 7upset | Box score |
| Nov 8, 1975 | Iowa 45, Wisconsin 28 | Box score |
| Nov 8, 1975 | Kansas 23, 2Oklahoma 3upset | Box score |
| Nov 8, 1975 | Kent State 30, Marshall 21 | Box score |
| Nov 8, 1975 | Long Beach State 10, Hawai’i 0 | Box score |
| Nov 8, 1975 | Louisiana Tech 41, UL Monroe 23 | Box score |
| Nov 8, 1975 | 16Maryland 21, Cincinnati 19 | Box score |
| Nov 8, 1975 | Memphis 17, Florida State 14 | Box score |
| Nov 8, 1975 | 17Miami (OH) 44, Western Michigan 21 | Box score |
| Nov 8, 1975 | 6Michigan 28, Purdue 0 | Box score |
| Nov 8, 1975 | Michigan State 14, Indiana 6 | Box score |
| Nov 8, 1975 | Minnesota 33, Northwestern 9 | Box score |
| Nov 8, 1975 | Auburn 21, Mississippi State 21 | Box score |
| Nov 8, 1975 | 19Missouri 44, Iowa State 14 | Box score |
| Nov 8, 1975 | 3Nebraska 12, Kansas State 0 | Box score |
| Nov 8, 1975 | NC State 15, 8Penn State 14upset | Box score |
| Nov 8, 1975 | 12Notre Dame 24, Georgia Tech 3 | Box score |
| Nov 8, 1975 | 1Ohio State 40, Illinois 3 | Box score |
| Nov 8, 1975 | Oregon State 7, Washington State 0 | Box score |
| Nov 8, 1975 | Pacific 19, Louisiana 14 | Box score |
| Nov 8, 1975 | Princeton 24, Harvard 20upset | Box score |
| Nov 8, 1975 | Richmond 7, The Citadel 0 | Box score |
| Nov 8, 1975 | San José State 29, New Mexico 20 | Box score |
| Nov 8, 1975 | Southern Miss 43, Lamar 3 | Box score |
| Nov 8, 1975 | Stanford 13, 9USC 10upset | Box score |
| Nov 8, 1975 | Tennessee 40, Utah 7 | Box score |
| Nov 8, 1975 | 7Texas 37, Baylor 21 | Box score |
| Nov 8, 1975 | 4Texas A&M 36, SMU 3 | Box score |
| Nov 8, 1975 | Texas Tech 34, TCU 0 | Box score |
| Nov 8, 1975 | Toledo 24, Northern Illinois 22 | Box score |
| Nov 8, 1975 | Tulsa 70, Drake 7 | Box score |
| Nov 8, 1975 | UCLA 50, Oregon 17 | Box score |
| Nov 8, 1975 | Vanderbilt 13, Kentucky 3 | Box score |
| Nov 8, 1975 | Virginia Tech 34, Houston 28 | Box score |
| Nov 8, 1975 | West Texas 38, New Mexico State 10 | Box score |
| Nov 8, 1975 | West Virginia 17, 20Pittsburgh 14upset | Box score |
| Nov 8, 1975 | Wichita State 28, Fresno State 11 | Box score |
| Nov 8, 1975 | William & Mary 13, VMI 7upset | Box score |
| Nov 8, 1975 | Yale 24, Pennsylvania 14 | Box score |