| Oct 27, 1973 | Air Force 41, Davidson 19 | Box score |
| Oct 27, 1973 | 2Alabama 77, Virginia Tech 6 | Box score |
| Oct 27, 1973 | App State 31, The Citadel 6 | Box score |
| Oct 27, 1973 | Arizona 42, Utah 21 | Box score |
| Oct 27, 1973 | 11Arizona State 44, Oregon State 14 | Box score |
| Oct 27, 1973 | Arkansas 20, Tulsa 6 | Box score |
| Oct 27, 1973 | Auburn 7, 12Houston 0upset | Box score |
| Oct 27, 1973 | Boston College 11, Villanova 7 | Box score |
| Oct 27, 1973 | Bowling Green 24, Marshall 21 | Box score |
| Oct 27, 1973 | Colorado 17, 7Missouri 13upset | Box score |
| Oct 27, 1973 | Colorado State 76, UTEP 24 | Box score |
| Oct 27, 1973 | Dartmouth 24, Harvard 18 | Box score |
| Oct 27, 1973 | Dayton 16, Drake 9 | Box score |
| Oct 27, 1973 | Holy Cross 17, Army 10 | Box score |
| Oct 27, 1973 | Illinois 50, Iowa 0 | Box score |
| Oct 27, 1973 | 17Kansas 22, Iowa State 20 | Box score |
| Oct 27, 1973 | Kent State 27, Utah State 16 | Box score |
| Oct 27, 1973 | Kentucky 12, Georgia 7upset | Box score |
| Oct 27, 1973 | Lamar 10, Arkansas State 7upset | Box score |
| Oct 27, 1973 | 9LSU 33, South Carolina 29 | Box score |
| Oct 27, 1973 | UL Monroe 14, 20Richmond 8upset | Box score |
| Oct 27, 1973 | Louisville 10, Cincinnati 8 | Box score |
| Oct 27, 1973 | Maryland 30, Duke 10 | Box score |
| Oct 27, 1973 | Miami 34, Syracuse 23 | Box score |
| Oct 27, 1973 | 16Miami (OH) 16, Toledo 0 | Box score |
| Oct 27, 1973 | 4Michigan 34, Minnesota 7 | Box score |
| Oct 27, 1973 | Michigan State 10, Purdue 7upset | Box score |
| Oct 27, 1973 | Ole Miss 24, Vanderbilt 14 | Box score |
| Oct 27, 1973 | Oklahoma State 17, 10Nebraska 17 | Box score |
| Oct 27, 1973 | North Carolina 28, East Carolina 27 | Box score |
| Oct 27, 1973 | NC State 29, Clemson 6 | Box score |
| Oct 27, 1973 | North Texas 27, New Mexico State 7 | Box score |
| Oct 27, 1973 | 8Notre Dame 23, 6USC 14upset | Box score |
| Oct 27, 1973 | Ohio 16, Western Michigan 0upset | Box score |
| Oct 27, 1973 | 1Ohio State 60, Northwestern 0 | Box score |
| Oct 27, 1973 | 3Oklahoma 56, Kansas State 14 | Box score |
| Oct 27, 1973 | Oregon 58, Washington 0 | Box score |
| Oct 27, 1973 | 5Penn State 62, West Virginia 14 | Box score |
| Oct 27, 1973 | Pennsylvania 24, Princeton 0 | Box score |
| Oct 27, 1973 | Pittsburgh 22, Navy 17 | Box score |
| Oct 27, 1973 | Rutgers 28, Columbia 2 | Box score |
| Oct 27, 1973 | San Diego State 38, Florida State 17 | Box score |
| Oct 27, 1973 | San José State 15, New Mexico 0 | Box score |
| Oct 27, 1973 | Mississippi State 10, Southern Miss 10 | Box score |
| Oct 27, 1973 | Stanford 45, Washington State 14 | Box score |
| Oct 27, 1973 | 14Tennessee 39, TCU 7 | Box score |
| Oct 27, 1973 | 19Texas 55, Rice 13 | Box score |
| Oct 27, 1973 | Texas A&M 28, Baylor 22 | Box score |
| Oct 27, 1973 | 18Texas Tech 31, SMU 14 | Box score |
| Oct 27, 1973 | Texas–Arlington 31, Louisiana 22 | Box score |
| Oct 27, 1973 | 15Tulane 23, Georgia Tech 14 | Box score |
| Oct 27, 1973 | 13UCLA 61, California 21 | Box score |
| Oct 27, 1973 | Virginia 21, Wake Forest 10 | Box score |
| Oct 27, 1973 | Wichita State 30, West Texas 14 | Box score |
| Oct 27, 1973 | William & Mary 45, VMI 14 | Box score |
| Oct 27, 1973 | Wisconsin 31, Indiana 7 | Box score |
| Oct 27, 1973 | Wyoming 41, BYU 21 | Box score |
| Oct 27, 1973 | Yale 20, Cornell 3 | Box score |