| Oct 12, 1973 | 14Houston 54, Virginia Tech 27 | Box score |
| Oct 12, 1973 | 16Miami 15, Boston College 10 | Box score |
| Oct 13, 1973 | 3Alabama 35, Florida 14 | Box score |
| Oct 13, 1973 | Arizona 22, New Mexico 14 | Box score |
| Oct 13, 1973 | 11Arizona State 28, San José State 3 | Box score |
| Oct 13, 1973 | Arkansas 13, Baylor 7 | Box score |
| Oct 13, 1973 | Brown 34, Yale 25upset | Box score |
| Oct 13, 1973 | Cincinnati 27, Louisiana 0 | Box score |
| Oct 13, 1973 | Clemson 32, Virginia 27 | Box score |
| Oct 13, 1973 | Colgate 22, Holy Cross 21upset | Box score |
| Oct 13, 1973 | 17Colorado 38, Air Force 17 | Box score |
| Oct 13, 1973 | Cornell 37, Princeton 6 | Box score |
| Oct 13, 1973 | Dayton 13, Ball State 12 | Box score |
| Oct 13, 1973 | East Carolina 42, VMI 7 | Box score |
| Oct 13, 1973 | Furman 38, Davidson 7 | Box score |
| Oct 13, 1973 | Georgia 20, Ole Miss 0 | Box score |
| Oct 13, 1973 | Harvard 57, Columbia 0 | Box score |
| Oct 13, 1973 | Illinois 15, Purdue 13 | Box score |
| Oct 13, 1973 | Iowa State 26, BYU 24 | Box score |
| Oct 13, 1973 | 19Kansas 25, Kansas State 18 | Box score |
| Oct 13, 1973 | Kent State 21, Bowling Green 7 | Box score |
| Oct 13, 1973 | Lamar 31, UTEP 27upset | Box score |
| Oct 13, 1973 | 10LSU 20, Auburn 6 | Box score |
| Oct 13, 1973 | Marshall 39, Northern Illinois 36upset | Box score |
| Oct 13, 1973 | Memphis 28, Tulsa 16 | Box score |
| Oct 13, 1973 | 20Miami (OH) 10, Ohio 6 | Box score |
| Oct 13, 1973 | 5Michigan 31, Michigan State 0 | Box score |
| Oct 13, 1973 | Minnesota 24, Indiana 3 | Box score |
| Oct 13, 1973 | Mississippi State 37, Florida State 12 | Box score |
| Oct 13, 1973 | 12Missouri 13, 2Nebraska 12upset | Box score |
| Oct 13, 1973 | Navy 23, Syracuse 14 | Box score |
| Oct 13, 1973 | North Carolina 16, Kentucky 10 | Box score |
| Oct 13, 1973 | NC State 24, Maryland 22 | Box score |
| Oct 13, 1973 | North Texas 7, Louisville 6upset | Box score |
| Oct 13, 1973 | Northwestern 31, Iowa 15 | Box score |
| Oct 13, 1973 | 9Notre Dame 28, Rice 0 | Box score |
| Oct 13, 1973 | 1Ohio State 24, Wisconsin 0 | Box score |
| Oct 13, 1973 | 6Oklahoma 52, 13Texas 13 | Box score |
| Oct 13, 1973 | Oregon 41, California 10 | Box score |
| Oct 13, 1973 | Oregon State 31, Washington 7upset | Box score |
| Oct 13, 1973 | Pacific 10, Long Beach State 6 | Box score |
| Oct 13, 1973 | 7Penn State 54, Army 3 | Box score |
| Oct 13, 1973 | Pennsylvania 22, Dartmouth 16upset | Box score |
| Oct 13, 1973 | Pittsburgh 35, West Virginia 7upset | Box score |
| Oct 13, 1973 | Richmond 42, Southern Miss 20 | Box score |
| Oct 13, 1973 | San Diego State 27, New Mexico State 0 | Box score |
| Oct 13, 1973 | South Carolina 28, Wake Forest 12 | Box score |
| Oct 13, 1973 | 4USC 46, Washington State 35 | Box score |
| Oct 13, 1973 | Southern Illinois 73, Xavier 7upset | Box score |
| Oct 13, 1973 | Tampa 17, Villanova 10 | Box score |
| Oct 13, 1973 | 8Tennessee 20, Georgia Tech 14 | Box score |
| Oct 13, 1973 | TCU 30, Idaho 14 | Box score |
| Oct 13, 1973 | Texas Tech 28, Texas A&M 16 | Box score |
| Oct 13, 1973 | 18Tulane 24, Duke 17 | Box score |
| Oct 13, 1973 | 15UCLA 59, Stanford 13 | Box score |
| Oct 13, 1973 | Utah 50, Wyoming 16 | Box score |
| Oct 13, 1973 | Utah State 34, Colorado State 18 | Box score |
| Oct 13, 1973 | Vanderbilt 20, William & Mary 7 | Box score |
| Oct 13, 1973 | Western Michigan 24, Toledo 22 | Box score |
| Oct 13, 1973 | Wichita State 18, Fresno State 13 | Box score |