| Oct 22, 1971 | San Diego State 36, Utah State 20 | Box score |
| Oct 23, 1971 | 20Air Force 17, Colorado State 12 | Box score |
| Oct 23, 1971 | 4Alabama 34, Houston 20 | Box score |
| Oct 23, 1971 | Arizona 14, Utah 3 | Box score |
| Oct 23, 1971 | 14Arizona State 60, New Mexico 28 | Box score |
| Oct 23, 1971 | 9Arkansas 60, North Texas 21 | Box score |
| Oct 23, 1971 | Army 14, Virginia 9 | Box score |
| Oct 23, 1971 | 5Auburn 35, Clemson 13 | Box score |
| Oct 23, 1971 | Boston College 40, Pittsburgh 22 | Box score |
| Oct 23, 1971 | Bowling Green 33, Miami (OH) 7 | Box score |
| Oct 23, 1971 | BYU 25, Tulsa 7 | Box score |
| Oct 23, 1971 | California 31, UCLA 24 | Box score |
| Oct 23, 1971 | Colgate 42, Brown 32 | Box score |
| Oct 23, 1971 | 11Colorado 27, Missouri 7 | Box score |
| Oct 23, 1971 | Columbia 17, Rutgers 16 | Box score |
| Oct 23, 1971 | Cornell 31, Yale 10 | Box score |
| Oct 23, 1971 | Dartmouth 16, Harvard 13 | Box score |
| Oct 23, 1971 | East Carolina 31, NC State 15upset | Box score |
| Oct 23, 1971 | Florida 27, Maryland 23 | Box score |
| Oct 23, 1971 | Florida State 49, South Carolina 18 | Box score |
| Oct 23, 1971 | Fresno State 47, Cal State Los Angeles 7 | Box score |
| Oct 23, 1971 | 8Georgia 34, Kentucky 0 | Box score |
| Oct 23, 1971 | Georgia Tech 24, Tulane 16 | Box score |
| Oct 23, 1971 | Idaho 26, West Texas 0 | Box score |
| Oct 23, 1971 | Illinois 21, 17Purdue 7upset | Box score |
| Oct 23, 1971 | Iowa State 40, Kansas 24 | Box score |
| Oct 23, 1971 | Kent State 24, Xavier 13 | Box score |
| Oct 23, 1971 | Long Beach State 31, California–Santa Barbara 10 | Box score |
| Oct 23, 1971 | Louisville 21, Wichita State 5 | Box score |
| Oct 23, 1971 | Memphis 27, Southern Miss 12 | Box score |
| Oct 23, 1971 | 3Michigan 35, Minnesota 7 | Box score |
| Oct 23, 1971 | Michigan State 34, Iowa 3 | Box score |
| Oct 23, 1971 | Ole Miss 28, Vanderbilt 7 | Box score |
| Oct 23, 1971 | Navy 15, 19Duke 14upset | Box score |
| Oct 23, 1971 | 1Nebraska 41, Oklahoma State 13 | Box score |
| Oct 23, 1971 | New Mexico State 20, Texas–Arlington 6 | Box score |
| Oct 23, 1971 | North Carolina 7, Wake Forest 3 | Box score |
| Oct 23, 1971 | Northwestern 24, Indiana 10 | Box score |
| Oct 23, 1971 | 12Ohio State 31, Wisconsin 6 | Box score |
| Oct 23, 1971 | 2Oklahoma 75, Kansas State 28 | Box score |
| Oct 23, 1971 | Oregon 34, San José State 14 | Box score |
| Oct 23, 1971 | 7Penn State 66, TCU 14 | Box score |
| Oct 23, 1971 | Princeton 31, Pennsylvania 0 | Box score |
| Oct 23, 1971 | USC 28, 6Notre Dame 14upset | Box score |
| Oct 23, 1971 | SMU 18, Texas Tech 17 | Box score |
| Oct 23, 1971 | Syracuse 63, Holy Cross 21 | Box score |
| Oct 23, 1971 | 18Tennessee 10, Mississippi State 7 | Box score |
| Oct 23, 1971 | 16Texas 39, Rice 10 | Box score |
| Oct 23, 1971 | Texas A&M 10, Baylor 9 | Box score |
| Oct 23, 1971 | UTEP 12, Wyoming 7 | Box score |
| Oct 23, 1971 | 14Toledo 35, Dayton 7 | Box score |
| Oct 23, 1971 | Villanova 24, Tampa 3 | Box score |
| Oct 23, 1971 | Virginia Tech 37, Ohio 29 | Box score |
| Oct 23, 1971 | Washington 38, Oregon State 14 | Box score |
| Oct 23, 1971 | Washington State 24, 10Stanford 23upset | Box score |
| Oct 23, 1971 | West Virginia 43, Temple 33 | Box score |
| Oct 23, 1971 | Western Michigan 37, Marshall 0 | Box score |
| Oct 23, 1971 | William & Mary 12, VMI 7 | Box score |