| Nov 7, 1969 | Miami 30, Navy 10 | Box score |
| Nov 8, 1969 | 19Air Force 38, Utah State 13 | Box score |
| Nov 8, 1969 | Arizona State 48, New Mexico 17 | Box score |
| Nov 8, 1969 | 4Arkansas 30, Rice 6 | Box score |
| Nov 8, 1969 | Oregon 17, Army 17 | Box score |
| Nov 8, 1969 | 11Auburn 52, Mississippi State 13 | Box score |
| Nov 8, 1969 | Bowling Green 23, Ohio 16 | Box score |
| Nov 8, 1969 | BYU 21, San José State 3 | Box score |
| Nov 8, 1969 | Buffalo 35, Boston College 21 | Box score |
| Nov 8, 1969 | California–Santa Barbara 28, Cal State Los Angeles 6 | Box score |
| Nov 8, 1969 | Cincinnati 31, Louisville 21 | Box score |
| Nov 8, 1969 | Colorado 17, Kansas 14 | Box score |
| Nov 8, 1969 | Cornell 14, Brown 7 | Box score |
| Nov 8, 1969 | Dartmouth 37, Columbia 7 | Box score |
| Nov 8, 1969 | Davidson 42, East Carolina 27 | Box score |
| Nov 8, 1969 | Dayton 27, Villanova 20upset | Box score |
| Nov 8, 1969 | Duke 34, Clemson 27 | Box score |
| Nov 8, 1969 | Virginia Tech 10, Florida State 10 | Box score |
| Nov 8, 1969 | 16Georgia 13, 13Florida 13 | Box score |
| Nov 8, 1969 | Houston 47, Tulsa 14 | Box score |
| Nov 8, 1969 | Iowa 28, Indiana 17upset | Box score |
| Nov 8, 1969 | Long Beach State 37, Fresno State 7 | Box score |
| Nov 8, 1969 | 12LSU 20, Alabama 15 | Box score |
| Nov 8, 1969 | Marshall 31, Kent State 20upset | Box score |
| Nov 8, 1969 | Memphis 37, Southern Miss 7 | Box score |
| Nov 8, 1969 | Miami (OH) 34, Maryland 21 | Box score |
| Nov 8, 1969 | 18Michigan 57, Illinois 0 | Box score |
| Nov 8, 1969 | Minnesota 28, Northwestern 21 | Box score |
| Nov 8, 1969 | 9Missouri 44, 20Oklahoma 10 | Box score |
| Nov 8, 1969 | 20Nebraska 17, Iowa State 3 | Box score |
| Nov 8, 1969 | New Mexico State 41, UTEP 38 | Box score |
| Nov 8, 1969 | North Carolina 61, VMI 11 | Box score |
| Nov 8, 1969 | North Texas 47, Wichita State 0 | Box score |
| Nov 8, 1969 | 8Notre Dame 49, Pittsburgh 7 | Box score |
| Nov 8, 1969 | 1Ohio State 62, Wisconsin 7 | Box score |
| Nov 8, 1969 | Oklahoma State 28, 15Kansas State 19upset | Box score |
| Nov 8, 1969 | Oregon State 35, California 3 | Box score |
| Nov 8, 1969 | Princeton 51, Harvard 20 | Box score |
| Nov 8, 1969 | 10Purdue 41, Michigan State 13 | Box score |
| Nov 8, 1969 | San Diego State 58, Pacific 32 | Box score |
| Nov 8, 1969 | 6USC 28, Washington State 7 | Box score |
| Nov 8, 1969 | 14Stanford 21, Washington 7 | Box score |
| Nov 8, 1969 | Syracuse 23, Arizona 0 | Box score |
| Nov 8, 1969 | 3Tennessee 29, South Carolina 14 | Box score |
| Nov 8, 1969 | 2Texas 56, Baylor 14 | Box score |
| Nov 8, 1969 | Texas A&M 20, SMU 10 | Box score |
| Nov 8, 1969 | TCU 35, Texas Tech 26 | Box score |
| Nov 8, 1969 | Toledo 35, Northern Illinois 21 | Box score |
| Nov 8, 1969 | Tulane 14, Georgia Tech 7 | Box score |
| Nov 8, 1969 | Utah 34, Wyoming 10 | Box score |
| Nov 8, 1969 | Vanderbilt 42, Kentucky 6 | Box score |
| Nov 8, 1969 | Wake Forest 23, Virginia 21upset | Box score |
| Nov 8, 1969 | West Texas 28, Western Michigan 20 | Box score |
| Nov 8, 1969 | West Virginia 31, William & Mary 0 | Box score |
| Nov 8, 1969 | Yale 21, Pennsylvania 3 | Box score |