| Nov 21, 1969 | Miami 49, Wake Forest 7 | Box score |
| Nov 22, 1969 | Arizona State 79, Colorado State 7 | Box score |
| Nov 22, 1969 | Bowling Green 38, Northern Illinois 23 | Box score |
| Nov 22, 1969 | Buffalo 24, Villanova 14 | Box score |
| Nov 22, 1969 | Colorado 45, Kansas State 32 | Box score |
| Nov 22, 1969 | Columbia 18, Brown 3upset | Box score |
| Nov 22, 1969 | Cornell 28, Pennsylvania 14 | Box score |
| Nov 22, 1969 | Duke 17, North Carolina 13 | Box score |
| Nov 22, 1969 | Florida State 33, NC State 22 | Box score |
| Nov 22, 1969 | 19Houston 41, Wyoming 14 | Box score |
| Nov 22, 1969 | Iowa 40, Illinois 0 | Box score |
| Nov 22, 1969 | 10LSU 27, Tulane 0 | Box score |
| Nov 22, 1969 | Maryland 17, Virginia 14 | Box score |
| Nov 22, 1969 | Memphis 69, Louisville 19 | Box score |
| Nov 22, 1969 | Miami (OH) 36, Cincinnati 20 | Box score |
| Nov 22, 1969 | 12Michigan 24, 1Ohio State 12upset | Box score |
| Nov 22, 1969 | Michigan State 39, Northwestern 7 | Box score |
| Nov 22, 1969 | Minnesota 35, Wisconsin 10 | Box score |
| Nov 22, 1969 | 7Missouri 69, Kansas 21 | Box score |
| Nov 22, 1969 | 16Nebraska 44, Oklahoma 14 | Box score |
| Nov 22, 1969 | New Mexico 24, New Mexico State 21upset | Box score |
| Nov 22, 1969 | 8Notre Dame 13, Air Force 6 | Box score |
| Nov 22, 1969 | Ohio 38, Marshall 35 | Box score |
| Nov 22, 1969 | Oklahoma State 35, Iowa State 0 | Box score |
| Nov 22, 1969 | Oregon State 10, Oregon 7 | Box score |
| Nov 22, 1969 | 4Penn State 27, Pittsburgh 7 | Box score |
| Nov 22, 1969 | Princeton 35, Dartmouth 7 | Box score |
| Nov 22, 1969 | 17Purdue 44, Indiana 21 | Box score |
| Nov 22, 1969 | Richmond 28, William & Mary 17 | Box score |
| Nov 22, 1969 | Rutgers 48, Colgate 12 | Box score |
| Nov 22, 1969 | San Diego State 42, North Texas 24 | Box score |
| Nov 22, 1969 | San José State 15, Pacific 12upset | Box score |
| Nov 22, 1969 | South Carolina 27, Clemson 13 | Box score |
| Nov 22, 1969 | 5USC 14, 6UCLA 12 | Box score |
| Nov 22, 1969 | SMU 12, Baylor 6 | Box score |
| Nov 22, 1969 | Southern Miss 14, East Carolina 7 | Box score |
| Nov 22, 1969 | 14Stanford 29, California 28 | Box score |
| Nov 22, 1969 | 9Tennessee 31, Kentucky 26 | Box score |
| Nov 22, 1969 | TCU 21, Rice 17 | Box score |
| Nov 22, 1969 | 20Toledo 35, Xavier 0 | Box score |
| Nov 22, 1969 | Utah 16, BYU 6 | Box score |
| Nov 22, 1969 | Utah State 31, Idaho 21 | Box score |
| Nov 22, 1969 | Vanderbilt 63, Davidson 8 | Box score |
| Nov 22, 1969 | Washington 30, Washington State 21 | Box score |
| Nov 22, 1969 | 18West Virginia 13, Syracuse 10 | Box score |
| Nov 22, 1969 | Wichita State 28, Tulsa 12 | Box score |
| Nov 22, 1969 | Yale 7, Harvard 0 | Box score |