| Nov 9, 1968 | Alabama 16, 20LSU 7upset | Box score |
| Nov 9, 1968 | Arizona 14, Air Force 10 | Box score |
| Nov 9, 1968 | Arizona State 59, Utah 21 | Box score |
| Nov 9, 1968 | 14Arkansas 46, Rice 21 | Box score |
| Nov 9, 1968 | Army 58, Boston College 25 | Box score |
| Nov 9, 1968 | 18Auburn 28, 5Tennessee 14upset | Box score |
| Nov 9, 1968 | Cincinnati 37, Louisville 7 | Box score |
| Nov 9, 1968 | Clemson 16, Maryland 0 | Box score |
| Nov 9, 1968 | Cornell 31, Brown 0 | Box score |
| Nov 9, 1968 | Dartmouth 31, Columbia 19 | Box score |
| Nov 9, 1968 | Florida State 27, Mississippi State 14 | Box score |
| Nov 9, 1968 | 9Georgia 51, Florida 0 | Box score |
| Nov 9, 1968 | Harvard 9, Princeton 7 | Box score |
| Nov 9, 1968 | 13Houston 27, Memphis 7 | Box score |
| Nov 9, 1968 | Indiana 24, 17Michigan State 22upset | Box score |
| Nov 9, 1968 | Iowa 68, Northwestern 34 | Box score |
| Nov 9, 1968 | Kansas State 12, Nebraska 0upset | Box score |
| Nov 9, 1968 | Kent State 36, Marshall 12 | Box score |
| Nov 9, 1968 | Miami (OH) 14, Dayton 0 | Box score |
| Nov 9, 1968 | 7Michigan 36, Illinois 0 | Box score |
| Nov 9, 1968 | Minnesota 27, 6Purdue 13upset | Box score |
| Nov 9, 1968 | 8Missouri 42, Iowa State 7 | Box score |
| Nov 9, 1968 | Navy 35, Georgia Tech 15upset | Box score |
| Nov 9, 1968 | New Mexico State 47, Wichita State 21 | Box score |
| Nov 9, 1968 | NC State 17, Duke 15 | Box score |
| Nov 9, 1968 | North Texas 34, UTEP 31 | Box score |
| Nov 9, 1968 | 12Notre Dame 56, Pittsburgh 7 | Box score |
| Nov 9, 1968 | 16Ohio 28, Bowling Green 27 | Box score |
| Nov 9, 1968 | 2Ohio State 43, Wisconsin 8 | Box score |
| Nov 9, 1968 | Oklahoma 27, 3Kansas 23upset | Box score |
| Nov 9, 1968 | Oklahoma State 34, Colorado 17upset | Box score |
| Nov 9, 1968 | Oregon 27, Washington State 13 | Box score |
| Nov 9, 1968 | 15Oregon State 45, UCLA 21 | Box score |
| Nov 9, 1968 | 4Penn State 22, Miami 7 | Box score |
| Nov 9, 1968 | South Carolina 34, Wake Forest 21 | Box score |
| Nov 9, 1968 | 1USC 35, 11California 17 | Box score |
| Nov 9, 1968 | SMU 36, Texas A&M 23 | Box score |
| Nov 9, 1968 | Stanford 35, Washington 20 | Box score |
| Nov 9, 1968 | Syracuse 31, William & Mary 0 | Box score |
| Nov 9, 1968 | Tampa 28, East Carolina 21 | Box score |
| Nov 9, 1968 | 10Texas 47, Baylor 26 | Box score |
| Nov 9, 1968 | Texas Tech 31, TCU 14 | Box score |
| Nov 9, 1968 | Tulane 25, Tulsa 15 | Box score |
| Nov 9, 1968 | Utah State 34, BYU 8 | Box score |
| Nov 9, 1968 | Vanderbilt 6, Kentucky 0 | Box score |
| Nov 9, 1968 | Virginia 41, North Carolina 6 | Box score |
| Nov 9, 1968 | VMI 21, Davidson 17 | Box score |
| Nov 9, 1968 | Virginia Tech 31, Richmond 18 | Box score |
| Nov 9, 1968 | West Texas 53, Western Michigan 36 | Box score |
| Nov 9, 1968 | West Virginia 17, The Citadel 0 | Box score |
| Nov 9, 1968 | Xavier 20, Toledo 10upset | Box score |
| Nov 9, 1968 | Yale 30, Pennsylvania 13 | Box score |